objective: gut–brain axis (gba) is very important in creation and modulation of gastrointestinal problems. aloe vera gel has gastroprotective properties. the purpose of this study was to evaluate the effect of aqueous extract of aloe vera leaves on the gastric acid secretion and brain and intestinal water content following acetic acid gastric ulcer induction. materials and methods: gastric ulce...

Hereditary predisposition is one of the aetiopathogenetic factors in development gastric ulcer and duodenal ulcer. The analysis literature materials allows us to identify a number candidate genes that play role formation peptic ulcer: PSCA, ABO, IL1β, IL1RN, TNFα, HSP70-1, GSR, TLR4, TLR2, TLR9, MMP-1, MMP-3, MMP- 9, TIMP-3, PGC, MIF, MPO, COX-1. Considering most studies were carried out abroad...

Pain site and radiation and the effect of various foods were studied prospectively in a consecutive series of patients with chronic upper abdominal pain. Patients followed for less than one year were excluded unless peptic ulcer or abdominal malignancy had been diagnosed or laparotomy had been carried out. A total of 632 patients were eligible for the first study and 431 for the second. Gastric...

peptic ulcer disease and its complications have long been studied but the coexistence of two major complications in a kissing ulcer is uncommon. we present our experience with this entity and review the related literature. a 27 year old man was suffering from concomitant major complication of duodenal kissing ulcer, huge anterior perforation and uncontrolled posterior bleeding, presenting as he...

abstract background: the role of psychological factors in peptic ulcer disease (pud) and functional dyspepsia (fd) has not been clearly determined. in this study the role of conflict management styles, psychiatric symptoms, and alexithymia were assessed in patients with pud and fd and in the healthy individuals. methods: ninety subjects [30pud (15 women, 15 men), 30 fd (15 women, 15 men), and 3...

The treatment of peptic ulcer is an ever increasing problem to the internist and surgeon alike. Those who attempt to treat the ulcer patient consrientiously are daily confused by the multiplicity of articles and conflicting results found in the literature today. There are many advocates of a strict antacid and dietary regimen and almost as many others claim that antacids and diet are valueless....

Helicobacter pylori (H. pylori) and non-steroidal anti-inflammatory drugs (NSAID) are major pathogenic factors in peptic ulcer disease but whether these two factors exert synergistic or antagonistic action on the gastric mucosa has been a subject of controversy. The classic concept states that there is an increased ulcer occurrence and bleeding in patients with both H. pylori infection and NSAI...