Dual antiplatelet therapy with aspirin and a P2Y12 receptor inhibitor represents the cornerstone therapy for patients with acute coronary syndromes or undergoing percutaneous interventions, leading to a reduction of subsequent ischemic events. Variable response to clopidogrel has received close attention, and pharmacokinetic, pharmacodynamic, and pharmacogenomic factors have been identified as ...

BACKGROUND Diabetic patients are at increased risk of adverse outcomes after percutaneous coronary interventions. Although subset analyses suggest particular benefit from the administration of abciximab in diabetic patients, no dedicated large randomized trials have been performed in diabetic patients undergoing percutaneous coronary intervention, and certainly not after pretreatment with a hig...

New advances in interventional cardiology and antithrombotic pharmacological treatment have modified the risk:benefit ratio of percutaneous interventions in acute coronary syndromes without ST segment elevation. In general terms, invasive strategies have two main limitations. The first stems from the fact that the severity of a coronary stenosis is not an index of the likelihood of the developm...

The prevalence of ischemic coronary artery disease (CAD) continues to be on the increase globally, more so in India. Indian spectrum of disease seem to be different in terms of early onset as well as complexity in presentation. Therapeutic options include pharmacological therapy, percutaneous coronary interventions (PCI), Coronary artery bypass surgery (CABG), and newer modalities of treatment ...

Like other invasive procedures, percutaneous coronary interventions are associated with complications. Most common access site for these procedures is common femoral artery. Complications such as groin and retroperitoneal hematoma can be encountered as well as pseudoaneurysms, arteriovenous fistulas, acute arterial occlusion, and infection. When infected pseudoaneurysm occurs, surgical treatmen...

BACKGROUND Coronary artery anomalies are rare, accounting for about 0.3-1.3% of patients undergoing diagnostic coronary angiography. Interventions in these cases are still rare, and therefore pose technical challenges during intervention. CT Angiography provides a non-invasive means of assessment of coronary artery disease and also shows the anatomy of the coronary tree. This helps in knowing t...

Percutaneous coronary intervention is the most prevalent method for coronary artery revascularization. Initial interventions using balloon angioplasty had limited efficacy because coronary dissections, arterial recoil, and neointimal formation led to high rates of abrupt vessel closure and clinical restenosis. With the introduction of coronary stents, vascular dissections were stabilized and ar...

ifurcation, the division of an artery into 2 branches, is a ommon anatomy feature of the human coronary tree and is ecognized as a common site for atherosclerotic plaque buildup ue to the differences in coronary flow, turbulence, and shear tress at the site of the bifurcation. The prevalence of bifurcaion stenosis in the human coronary tree is reported to be etween 15% to 20% of all interventio...

Percutaneous revascularisation in anomalous coronary arteries poses certain technical difficulties, especially in the selective cannulation of the diseased vessel and the coaxial positioning of the guiding catheter for optimum stability. We report a case of successful stent implantation in a single coronary artery (SCA) arising from the right sinus of Valsalva (SoV). The ART 4 (Boston Scientifi...

Periprocedural myocardial infarction is a potential problem of percutaneous coronary intervention. Even after seemingly uncomplicated, straightforward elective coronary interventions, elevation of cardiac enzymes can be observed and occur in approximately one-third of cases (1). Such enzyme elevations have been shown to be associated with myocardial injury, for example, by magnetic resonance st...