PURPOSE To present a technique of ocular sectioning that enables continuous histologic measurements of peripapillary retinal nerve fiber layer (RNFL) thickness in a concentric ring around the optic disc, corresponding to similar regions measured by in vivo imaging techniques. METHODS Two pig eyes and two normal human eyes were processed using the "umbrella" technique, in which peripapillary c...

PURPOSE To evaluate the effect of pattern scan laser (PASCAL) photocoagulation on peripapillary retinal nerve fiber layer (RNFL) thickness, central macular thickness (CMT), and optic nerve morphology in patients with diabetic retinopathy. METHODS Subjects included 35 eyes for the PASCAL group and 49 eyes for a control group. Peripapillary RNFL thickness, cup-disc area ratio and CMT were measu...

The impairment of retinal vascular autoregulation can be an early manifestation of many systemic and ocular diseases. Therefore, quantifying retinal vascular autoregulation in a non-invasive manner is very important. This study evaluated the effects of a Valsalva maneuver (VM)-induced blood pressure increases on retinal vascular autoregulation. Parafoveal and peripapillary retinal vessel densit...

PURPOSE To investigate the relationship between retinal light sensitivity measured with standard automated perimetry (SAP) and retardation of the peripapillary retinal nerve fiber layer (RNFL) measured with the GDx VCC (Laser Diagnostic Technologies, Inc., San Diego, CA). METHODS Forty-seven healthy subjects and 101 patients with glaucoma were examined with SAP and with the commercially avail...

BACKGROUND Peripapillary choledochoduodenal fistula (PCDF) is occasionally detected during endoscopic retrograde cholangiopancreatography. This study was designed to compare perioperative outcomes of the peripapillary choledochoduodenal fistula with bile duct stones via endoscopic papillary balloon dilatation and conventional endoscopic sphincterotomy. METHODS We retrospectively reviewed 28 p...

PURPOSE To investigate the central macular thickness (CMT) in myopic, emmetropic, and hyperopic Chinese children using Optical Coherence Tomography. METHODS 168 right eyes of Chinese subjects aged 4-18 were divided into 3 groups based on their postcycloplegic spherical equivalent: myopes (<-1.0 D); emmetropes (≥-1.0 to ≤+1.0 D); and hyperopes (>+1.0 D) and the CMT was compared before/after ag...

OBJECTIVE To evaluate changes in peripapillary and macular choroidal thickness and volume after the water-drinking test (WDT) using swept-source optical coherence tomography (SS OCT). DESIGN Prospective, cross-sectional, observational study. PARTICIPANTS Fifty-six eyes of 28 healthy volunteers. METHODS Participants underwent a 3-dimensional optic disc and macula scanning protocol with a p...

PURPOSE The authors report the ophthalmic characteristics of a male proband in a Japanese family with autosomal dominant optic atrophy (DOA) harboring a frameshift mutation in the OPA1 gene. METHODS Conventional ophthalmologic examinations including static automated perimetry were performed, as well as assessment of the three-generation family history. The peripapillary retinal nerve fiber la...

BACKGROUND The effect of pancreas transplantation on diabetic retinopathy remains inconclusive. Herein, we report six patients with type 1 diabetes mellitus (DM) who underwent pancreas transplantation and developed acute macular edema and peripapillary soft exudate with rapid progression to proliferative diabetic retinopathy. METHODS In this retrospective observational study, diabetic patient...

BACKGROUND Choroidal neovascularization (CNV) is a rare complication of intermediate uveitis. Risk factors are not well-characterized. Here, we describe a case of peripapillary CNV in a patient with intermediate uveitis and explore the pathophysiology and treatment of this condition. This study is a case report and review of the literature. RESULTS A 15-year-old boy with intermediate uveitis ...