Abstract The concept of myeloid derived suppressive cells (MDSCs) has emerged in recent years as a group that pocess potent immunosuppressive activity. These expand under pathologic conditions and suppress the immune functions T cells, dendritic macrophages, natural killer cells. They have been shown to be involved pathological states cancer, autoimmune diseases, infections, such COVID-19. MDSC...

Within the normal human epidermis only Langerhans and indeterminate cells express HLA-DR. Human keratinocytes (HK), however, may also express HLA-DR in certain disease states characterized by mononuclear cell infiltrates. Previous studies have shown that HK synthesize HLA-DR in response to stimulation by interferon gamma (INF-gamma). The purposes of this study were to define conditions under wh...

Vechur cattle, an indigenous breed of Kerala and it is the smallest cattle in world. They are highly disease resistant. The occurrence mastitis very Rare this as compared to crossbred cattle. Rearing these more cost effective they require less feed. Therefore, characterisation factors involved immune system breeds might provide insight into mechanisms variation resistance. Toll-like receptors (...

Abstract Mounting evidence supports a role for the immune system in pathophysiology of dementia. Alterations composition circulating cells is one key changes associated with age. However, age and sex on cell phenotypes their contribution to disease pathogenesis remains be unraveled. We identified study sample 996 participants (mean 62 years, range 40 88 52% female, 22% APOE-ϵ4 carriers) from co...

Identification of the factors which impact on the transmission of human immunodeficiency virus type 1 (HIV-1) from an infected mother to her infant is essential for the development of effective strategies to prevent perinatal HIV-1 infection. The current study was designed to determine if unstimulated human neonatal cord blood mononuclear cells (CBMC) differ from adult peripheral blood mononucl...

BACKGROUND Acute myocardial infarction (AMI) is followed by post AMI cardiac remodelling, often leading to congestive heart failure. Homing of c-kit+ endothelial progenitor cells (EPC) has been thought to be the optimal source for regenerating infarcted myocardium. METHODS Immune function of viable peripheral blood mononuclear cells (PBMC) was evaluated after co-culture with irradiated apopto...

Squamous cell carcinomas of the head and neck (SCCHN) often contain a large mononuclear cell infiltrate, composed mainly of T-lymphocytes which could reflect an in situ immune reaction against the malignant SCCHN cells. We analyzed the molecular structure of the T-cell receptor (TCR) alpha and beta chains expressed by lymphocytes in the tumor, peripheral blood (PBMC), and in the peritumoral tis...

Broadly directed hepatitis C virus (HCV)-specific cytotoxic T lymphocytes (CTL) have been identified from liver-infiltrating lymphocytes but have been more difficult to assess in peripheral blood of infected persons. To enhance the detection of CTL from peripheral blood mononuclear cells (PBMC), we cocultured PBMC with autologous Epstein-Barr virus-transformed B-lymphoblastoid cell lines that h...

Human neutrophils express two types of low affinity receptors for IgG, Fc gamma RII or CD32 and Fc gamma RIIIB or CD16. Human serum contains soluble CD16 (sCD16), which is produced by proteolysis of neutrophil Fc gamma RIIIB, the cleavage site being located close to the cell surface. In order to assess the functional roles of sCD16, we have produced, in eukaryotic cells, a recombinant sCD16 con...

Here, we report data concerning the discovery in adult human peripheral blood of a precursor cell population able to differentiate into CD4+CD3+ alpha beta + mature T cells. These cells, which represent 0.1-0.5% of total peripheral blood mononuclear cells (PBMC), express substantial levels of CD4, but lack CD3 surface expression. At a molecular level, they express the pre-T cell receptor alpha ...