Peripheral nerve transection and neuroma-in-continuity injuries are associated with permanent functional deficits, often despite successful end-organ reinnervation. Axonal misdirection with non-specific reinnervation, frustrated regeneration and axonal attrition are believed to be among the anatomical substrates that underlie the poor functional recovery associated with these devastating injuri...

Introduction: Repair of peripheral nerve injuries is an intensive area of challenge and research in modern reconstructive microsurgery. Intensive research is being carried out to develop effective alternatives to the standard nerve autografting, avoiding its drawbacks. The aim of the study was to evaluate the effectiveness of a newly designed mechanical device for the reconstruction of the...

“A clever person solves the problem. A wise avoids it” (Albert Einstein). There is no convincing evidence that any modality 100% effectively prevents nerve injury. The risk of injury remains same even with ultrasound due to limitations in resolution images and inter-operator inter-patient differences. In a nutshell, caution required when dealing precious nerves perioperative period, either duri...

Interscalene brachial plexus block provides effective anesthesia and analgesia for shoulder surgery. One of the disadvantages of this technique is the risk of hemidiaphragmatic paresis, which can occur as a result of phrenic nerve block and can cause a decrease in the pulmonary function, limiting the use of the block in patients with reduced functional residual capacity or a preexisting pulmona...

Wallerian degeneration is an innate immune response which occurs after some kinds of nerve damages such as neurodegenerative disease and acute axonal injury. In clinic, dexamethasone as an anti-inflammatory drug has been used for many years to treat nerve injuries. In present study, we aimed to study the effects of various doses of dexamethasone on the Wallerian degeneration in rat. Twentyseven ...

Peripheral nerves are susceptible to a variety of injuries, often with coexistent orthopaedic trauma. Although the presence of nerve involvement in many circumstances may be clinically obvious, an appropriate therapeutic approach depends on more detailed information regarding the nature of the lesion. Electrodiagnostic studies (nerve conduction studies [NCS] and needle electromyography [EMG]) c...

the effect of nerve growth factor (ngf) on regeneration of rat sciatic nerves in adult rat was studied. the sciatic nerve was cut out across a 6‑mm gap, then the proximal and distal stumps were inserted into the silicone tube chamber. 7s ngf was extracted from submaxillary gland and then was injected into the silicone in experimental group. after seven months nerve was transected and stained wi...