BACKGROUND Superparamagnetic nanoparticles are currently used as contrast agents for magnetic resonance imaging. These particles can also be used as drug carriers for local chemotherapy, called magnetic drug targeting. Using an external magnetic field, colloidal nanoparticles can be directed to a specific body compartment (i.e. tumor). MATERIALS AND METHODS After magnetic drug targeting in an...

Broncho alveolar lavage is the most commonly used diagnostic tool for confirming alveolar hemorrhage. Golde has introduced a ranking score, based on the hemosiderin content of macrophages which enables ranking cells from 0 to 4 based on the degree of Prussian blue stain. We propose a complete image analysis scheme to automatically perform both the extraction of the cellular objects and the rank...

The brain uses iron for many essential processes (1-4). The extent of iron utilization is heavily dependent on local functional requirements, leading to significant variations in tissue iron concentrations throughout the brain (5-7). This was graphically illustrated nearly a century ago in the first colour illustrations of the differential distribution of iron throughout the brain architecture,...

Films of Prussian Blue (PB) deposited by electroreduction in the absence of K + have absorbance maxima at 730 nm which narrow and shift on voltammetric cycling in KCI solution to 690 nm, these absorptions being deemed diagnostic of 'insoluble' and 'soluble' PB respectively. Spectroelectrochemistry shows that the initial deposit even in K + solution is invariably the insoluble form, being then c...

OBJECTIVES To validate the feasibility of labeling Clostridium novyi-NT (C.novyi-NT) anaerobes with iron-oxide nanoparticles for magnetic resonance imaging (MRI) and demonstrate the potential to use MRI to visualize intra-tumoral delivery of these iron-oxide labeled C.novyi-NT during percutaneous injection procedures. MATERIALS AND METHODS All studies were approved by IACUC. C.novyi-NT were l...

*Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China. Arrhythmia Research Lab, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. School of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. ***13442 SW 102 Lane Miami, FLA, 33186. Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Okl...

The Miissbauer spectra and magnetic susceptibilities have been obtained for a series of Prussian Blue analogues of general formula MjAIMB(CN)&.mHzO where MA and MB are transition metal ions, j and k vary with the oxidation states of MA and MB and m typically has values from 8 to 14. The compounds were prepared from the hexacyano acids or with large quaternary ammonium counterions and are theref...