BACKGROUND Worldwide, pertussis remains a major health problem among children. During the recent outbreaks of pertussis, maternal antenatal immunisation was introduced in several industrial countries. This systematic review aimed to synthesize evidence for the efficacy and safety of the pertussis vaccination that was given to pregnant women to protect infants from pertussis infection. METHODS...

OBJECTIVE To determine long term outcome in children who had a severe acute neurological illness in early childhood associated with pertussis immunisation. DESIGN Follow up study of cases and matched controls. SETTING Assessment of children at home and at school throughout Britain. SUBJECTS Children recruited into the national childhood encephalopathy study in 1976-9 were followed up, wit...

BACKGROUND In the United States, children receive five doses of diphtheria, tetanus, and acellular pertussis (DTaP) vaccine before 7 years of age. The duration of protection after five doses of DTaP is unknown. METHODS We assessed the risk of pertussis in children in California relative to the time since the fifth dose of DTaP from 2006 to 2011. This period included a large outbreak in 2010. ...

BACKGROUND Pertussis vaccination in infancy has been suggested to increase the risk for development of asthma and allergy. OBJECTIVE To assess sensitization rates and development of atopic diseases in a prospective randomized controlled trial of pertussis vaccine. PATIENTS AND METHODS A total of 669 children were randomized to 1 of 4 vaccine groups (2-component acellular pertussis, 5-compon...

BACKGROUND: During the 1990s, the United States switched from combined diphtheria, tetanus toxoids, whole-cell pertussis (DTwP) vaccines to combined acellular pertussis (DTaP) vaccines because of safety concerns. After a 2010–2011 pertussis outbreak, we sought to evaluate whether disease risk in 10 to 17 year olds differed between those who previously received DTwP from those who received DTaP....

The authors have indicated that 95% of objects have had complete immunization records against B. pertussis but only 35% had protective antibody against B. pertussis 1 . It has been proven that there is no accurate method to analyze the protection level after B. pertussis vaccination, so what does seropositive mean? It means that the object has recently caught the natural infection. Knowing this...

Acellular vaccines against Bordetella pertussis were introduced in Australia in 1997. By 2000, these vaccines had replaced whole-cell vaccines. During 2008-2012, a large outbreak of pertussis occurred. During this period, 30% (96/320) of B. pertussis isolates did not express the vaccine antigen pertactin (Prn). Multiple mechanisms of Prn inactivation were documented, including IS481 and IS1002 ...

BACKGROUND An outbreak of pertussis occurred in a daycare center with 87.5% vaccination coverage. OBJECTIVES To assess the effectiveness of the acellular pertussis vaccine and prevention of pertussis after chemoprophylaxis with azithromycin. METHODS We studied 31 daycare children aged 3-5.5 years exposed to a child with pertussis. Nasopharyngeal swabs were obtained for Bordetella pertussis ...

BACKGROUND Infants with pertussis infection are at risk of severe clinical illness and death. Several countries, including the United Kingdom, have introduced maternal pertussis vaccination during pregnancy to protect infants from infection following national increases in pertussis notifications. The objective of this study was to estimate the effectiveness of maternal pertussis vaccination in ...

Pertussis vaccines vary in quality, safety, and efficacy according to the production strains of Bordetella pertussis, the method of manufacture, and quality control procedures. It is therefore not justifiable to combine information on the incidence, nature, and severity of reactions after all manufacturers' pertussis vaccines as if they were a single product. Attempts were made to collect infor...