Introduction Efforts to combine anatomical and functional imaging modalities have resulted in the development and widespread use of PET/CT systems. PET/MRI would offer improved soft tissue contrast, highresolution anatomical information and would benefit longitudinal studies due to reduced dose. Combining conventional PET and MRI faces numerous technical challenges, particularly the sensitivity...

A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new ...

Huazhong University of Science & Technology, Hubei, China Nowadays the simultaneous PET/MRI is being paid more and more attentions. Since MRI provides a high resolution, unsurpassed soft tissue contrast imaging and PET reveal the metabolism progress in molecular level, it is reasonable to believe the PET/ MRI will be a powerful tool to improve the understanding of pathogenesis and mechanism of ...

PURPOSE Hybrid positron emission tomography (PET)/magnetic resonance (MR) imaging systems have recently been built that allow functional and anatomical information obtained from PET and MR to be acquired simultaneously. The authors have developed a robust coregistration scheme for a first generation small animal PET/MR imaging system and illustrated the potential of this system to study intratu...

Toxoplasma gondii is an intracellular protozoan parasite that causes toxoplasmosis and is of medical importance in pregnant women and immunosuppressed patients. In recent years, many methods have been developed for the detection of infection caused by this parasite; however, most of the developed methods are not adequately sensitive. The dense granular antigen (GRA) ...

Abstract Background Integrated whole-body PET/MR technology continues to mature and is now extensively used in clinical settings. However, due the special design architecture, integrated comes with a few inherent limitations. Firstly, lacks sensitivity resolution for focused organs. Secondly, broader access of has been significantly restricted its prohibitively high cost. The MR-compatible PET ...

PURPOSE Treatment of patients with diffuse large B cell lymphoma (DLBCL) includes rituximab, an anti-CD20 monoclonal antibody (mAb). Insufficient tumor targeting might cause therapy failure. Tumor uptake of 89Zirconium (89Zr)-mAb is a potential imaging biomarker for tumor targeting, since it depends on target antigen expression and accessibility. The aim of this pilot study was to describe the ...

A series of experiments on the synthesis of poly (ethylene terephthalate) (PET)/organo-montmorillonite (MMT) nanocomposites were carried out in a pressurized reactor using alkyl ammonium exchanged smectite clays, (Closite 30B).Given the degradation of organoclay at high temperatures, the in situ polymerization process was carried out at mild temperatures ranging from 210 to 230°C for 40 minutes...

The plasmid vector pET-28b(+) named “Young” was produced according a work of 2014.1 This construct is designed to allow the expression 13.6 kDA protein with C-terminal 6histag. It supposed be an anti-HRP (Horse-radish peroxydase protein). not expressed in first E. coli: we attempt explain this phenomenon.

BACKGROUND The integrin alphavbeta3 plays an important role in angiogenesis and tumor cell metastasis, and is currently being evaluated as a target for new therapeutic approaches. Several techniques are being studied to enable noninvasive determination of alphavbeta3 expression. We developed [(18)F]Galacto-RGD, a (18)F-labeled glycosylated alphavbeta3 antagonist, allowing monitoring of alphavbe...