نتایج جستجو برای: pet oligomers
تعداد نتایج: 63221 فیلتر نتایج به سال:
Over the past several years, TDA Research, Inc. has been developing solvent processable forms of poly(3,4-ethylenedioxythiophene) commonly known as "PEDOT". Our approach is to make block copolymers with alternating conducting and non-conducting blocks. The conducting segments provide the electronic properties, while the non-conducting segments are designed to promote dispersion. TDA has two lin...
تصویربرداری pet یکی از روشهای مقطع نگاری در پزشکی هسته ای می باشد. حساسیت و رزولوشن مکانی بیشتر و نیز قابلیت کمّی سازی بهتر، از مزایای تصویربرداری pet در مقایسه با spect می باشد. هر چند که سطح بالای نویز در این تصاویر صحت تشخیص را کاهش می دهد. بطور معمول، حذف/ کاهش نویز در پزشکی هسته ای بر پایه تبدیل فوریه تصاویر می باشد. این تبدیل، محتوای فرکانسی یک سیگنال/ تصویر را بدست می دهد اما در مورد مکان...
Amylin is an endocrine hormone and is a member of the family of amyloid peptides and proteins that emerge as potential scaffolds by self-assembly processes. Zn(2+) ions can bind to amylin peptides to form self-assembled Zn(2+)-amylin oligomers. In the current work the binding sites of Zn(2+) ions in the self-assembled amylin oligomers at various concentrations of zinc have been investigated. Ou...
Amyloid beta (Abeta) oligomers accumulate in brain tissue of Alzheimer disease patients and are related to pathogenesis. The precise mechanisms by which Abeta oligomers cause neurotoxicity remain unresolved. In this study, we investigated the role of ionotropic glutamate receptors on the intracellular Ca2+ overload caused by Abeta. Using rat cortical neurons in culture and entorhinal-hippocampa...
The extent of triplet state delocalization is investigated in rigid linear zinc porphyrin oligomers as a function of interporphyrin bonding characteristics, specifically in meso-meso singly linked and β,meso,β fused structures, using electron paramagnetic resonance techniques. The results are compared with those of earlier measurements on porphyrin oligomers with alkyne linkers exhibiting diffe...
Alzheimer's disease (AD) is a devastating neurodegenerative disorder and a major medical problem. Here, we have investigated the impact of amyloid-β (Aβ) oligomers, AD-related neurotoxins, in the brains of rats and adult nonhuman primates (cynomolgus macaques). Soluble Aβ oligomers are known to accumulate in the brains of AD patients and correlate with disease-associated cognitive dysfunction. ...
Antisense oligomers constitute an attractive class of specific tools for genetic analysis and for potential therapeutic applications. Targets with different cellular locations have been described, such as mRNA translation initiation sites, pre-mRNA splicing sites, or the genes themselves. However the mechanism(s) of action and the intracellular distribution of antisense oligomers remain poorly ...
PNA is a nucleic acid analog with an achiral polyamide backbone consisting of N-(2-aminoethyl)glycine units (figure 1). The purine or pyrimidine bases are linked to the each unit via a methylene carbonyl linker (1-3) to target the complementary nucleic acid (4). PNA binds to complementary RNA or DNA in a parallel or antiparallel orientation following the Watson-Crick base-pairing rules (5-7). T...
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