Background Cerebral hypoperfusion is a pivotal risk factor for vascular dementia (VD), for which effective therapy remains inadequate. Persistent inflammatory responses and excessive chemotaxis of microglia/macrophages in the brain may accelerate the progression of VD. Endocannabinoids are involved in neuronal protection against inflammation-induced neuronal injury. Cannabinoids acting at canna...

ObjectivesThe diagnosis of tuberculosis pleural effusion (TPE) remains challenging, traditional diagnostic tests have limited efficacy. This study aimed to assess the performance fluid (PF) lipoarabinomannan (LAM) in TPE.MethodsA method for PF LAM (LAM-PF) was established using LEDBIO's AIMLAM kit. The LAM-PF evaluated 162 HIV-negative patients with suspected TPE.ResultsThe this exhibited good ...

Phenol-formaldehyde (PF) resin is one of the most well-known adhesives for exterior use. PF adhesive commercial thermoset polymers that used extensively due to its many benefits. This study investigated influence different types and levels catalysts, i.e., NaOH CaCO3 at 1% 5% based on solids content properties, adhesion, cohesion strength resin. The results show catalyst type significantly infl...

Osmotic water permeability (Pf) in toad bladder is regulated by the vasopressin (VP)-dependent movement of vesicles containing water channels between the cytoplasm and apical membrane of granular cells. Apical endosomes formed in the presence of serosal VP have the highest Pf of any biological or artificial membrane (Shi and Verkman. 1989. J. Gen. Physiol. 94:1101-1115). We examine here: (a) th...

INTRODUCTION We report data from adult and pediatric patients with severe sepsis from studies evaluating drotrecogin alfa (activated) (DrotAA) and presenting with purpura fulminans (PF), meningitis (MEN), or meningococcal disease (MD) (PF/MEN/MD). Such conditions may be associated with an increased bleeding risk but occur in a relatively small proportion of patients presenting with severe sepsi...

HYPOTHESIS Predictive factors of pancreatic fistula (PF) and the value of conservative management of PF following distal pancreatectomy (DP) are poorly known. DESIGN Case series. SETTING A university hospital referral center. PATIENTS From 1991 to 2003, 175 patients underwent DP with routine drainage of the pancreatic stump and postoperative repeated measures in drainage fluid. Pancreatic...

This is Part I of a two-part paper series that studies the use of the proportional fairness (PF) utility function as the basis for capacity allocation and scheduling in multi-channel multi-rate wireless networks. The contributions of Part I are threefold. (i) First, we lay down the theoretical foundation for PF. Specifically, we present the fundamental properties and physical/economic interpret...

Penile fracture (PF) is considered an emergency in urology. In the literature there are some case series reporting considerable incidence of PF in some parts of Iran. There are no accurate data about the incidence of PF all around Iran. Although it may be uncommon in other parts of the country and in the other countries, it can also be underreported. There are some challenges in diagnosis, mana...

PURPOSE We aimed to assess the biologic activity of PF-03084014 in breast xenograft models. The biomarkers for mechanism and patient stratification were also explored. EXPERIMENTAL DESIGN The in vitro and in vivo properties of PF-03084014 were investigated. The mRNA expressions of 40 key Notch pathway genes at baseline or after treatment were analyzed to link with the antitumor efficacy of PF...

Restoration of an epidermal barrier is a definitive requirement for wound closure. To determine formation of an epidermal barrier as a function of hydration of the stratum corneum, we measured surface electrical capacitance (SEC) of the epidermis in cultured skin substitutes (CSS) in vitro and after grafting to athymic mice. CSS were prepared from human keratinocytes and fibroblasts attached to...