نتایج جستجو برای: pfcrt
تعداد نتایج: 384 فیلتر نتایج به سال:
Analysis of the PfCRT K76T Mutation inPlasmodium falciparumIsolates from the Amazon Region of Brazil
Drug resistance in Plasmodium falciparum is a serious public health threat in the countries where this organism is endemic. Since resistance has been associated with specific single-nucleotide polymorphisms (SNPs) in parasite genes, molecular markers are becoming useful surrogates for monitoring the emergence and dispersion of drug resistance. In this study, a multiplex PCR (mPCR) and oligonucl...
Antimalarial chemotherapy, globally reliant on artemisinin-based combination therapies (ACTs), is threatened by the spread of drug resistance in Plasmodium falciparum parasites. Here we use zinc-finger nucleases to genetically modify the multidrug resistance-1 transporter PfMDR1 at amino acids 86 and 184, and demonstrate that the widely prevalent N86Y mutation augments resistance to the ACT par...
In Uganda, artemether-lumefantrine was introduced as an artemisinin-based combination therapy (ACT) for malaria in 2006. We have previously reported a moderate decrease ex vivo efficacy of lumefantrine Northern where we also detected artemisinin-resistant Plasmodium falciparum. Therefore, it is necessary to search candidate partner alternatives ACT. Here, investigated susceptibility four ACT dr...
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