Submit Manuscript | http://medcraveonline.com Abbreviations: APOA1: Apolipoprotein A1; APOB: Apolipoprotein B; ATP: Adenosine Triphosphate; BMI: Body Mass Index; CRP: Cardio-Reactive Protein; DAG: Diacylglycerol or Diglyceride; FACoA: Fatty Acyl CoA; HbA1C: Hemoglobin A1c; HOMA-IR: Homeostatic Model Assessment of Insulin Resistance; HDL: High-Density Lipoprotein cholesterol; HSCRP: Highly Sensi...

Brown algae and its carotenoids have been shown to have a positive influence on obesity and its comorbidities. This study evaluated the effect of Undaria pinnatifida and fucoxanthin on biochemical, physiological and inflammation markers related to obesity and on the expression of genes engaged on white adipose tissue lipid metabolism in a murine model of diet-induced obesity. The treatments imp...

Exercise has been shown to be effective for treating obesity and type 2 diabetes. However, the molecular mechanisms for adaptation to exercise training are not fully understood. Endoplasmic reticulum (ER) stress has been linked to metabolic dysfunction. Here we show that the unfolded protein response (UPR), an adaptive response pathway that maintains ER homeostasis upon luminal stress, is activ...

Brown adipose tissue (BAT) dissipates chemical energy as heat and can counteract obesity. MicroRNAs are emerging as key regulators in development and disease. Combining microRNA and mRNA microarray profiling followed by bioinformatic analyses, we identified miR-455 as a new regulator of brown adipogenesis. miR-455 exhibits a BAT-specific expression pattern and is induced by cold and the brownin...