Aim To provide a detailed gene and protein expression analysis related to mitochondrial biogenesis assess content in skeletal muscle of children with cerebral palsy (CP). Method Biceps brachii samples were collected from 19 CP (mean [SD] age 15y 4mo [2y 6mo], range 9–18y, 16 males, three females) 10 typically developing comparison [4y], 7–21y, eight two females). Gene (quantitative reverse tran...

The present study was designed to investigate the role of the medial preoptic nucleus (MPO) as a site of the thermogenic and metabolic effects of the α-melanocyte-stimulating hormone analog melanotan II (MTII). We also assessed the involvement of the dorsomedial hypothalamic nucleus (DMH) by investigating the effects of the MPO infusion of MTII in rats with DMH lesions produced by kainic acid. ...

Abstract Background Parkinson’s disease (PD) is a multifactorial neurodegenerative disorder marked by the death of nigrostriatal dopaminergic neurons in response to compounding effects oxidative stress, mitochondrial dysfunction and protein aggregation. Transgenic Drosophila models have been used extensively decipher underlying genetic interactions that exacerbate neural health PD. Autosomal re...