نتایج جستجو برای: phage library

تعداد نتایج: 138241  

2016
Xuewei Pan Xiaoli Cui Fenjiao Zhang Yang He Lingyan Li Hongjiang Yang

Phage therapy requires the comprehensive understanding of the mechanisms underlying the host-phage interactions. In this work, to identify the genes related to Pseudomonas aeruginosa phage K8 receptor synthesis, 16 phage-resistant mutants were selected from a Tn5G transposon mutant library of strain PAK. The disrupted genetic loci were identified and they were related to O-specific antigen (OSA...

2012
N Aghabeigi N Lindsey A Zamani B Shishaeyan

BACKGROUND The autoimmune disease known as Idiopathic (immune thrombocytopenic purpura thrombocytopenic purpura (ITP) is clinically defined by a low numbers of platelets in the circulation blood. This study aimed to isolate autoantibodies made against the platelet glycoproteins using platelets from healthy volunteers, to determine their specificity and further elucidate their effects on platele...

2017
Yurie Enomoto-Okawa Yuka Maeda Nozomi Harashima Yumika Sugawara Fumihiko Katagiri Kentaro Hozumi Kam Man Hui Motoyoshi Nomizu Yuji Ito Yamato Kikkawa

The Lutheran glycoprotein (Lu), also known as basal cell adhesion molecule (B-CAM), is an Ig superfamily (IgSF) transmembrane receptor for laminin α5. Although Lu is not present in normal hepatocytes, its expression is significantly increased in hepatocellular carcinoma (HCC). In this study, we isolated thirteen phage antibodies to Lu from a phage library of peripheral blood from HCC patients, ...

2014
Xing Liu Yang Xu Yong-hua Xiong Zhui Tu Yan-ping Li Zhen-yun He Yu-lou Qiu Jin-heng Fu Shirley J. Gee Bruce D. Hammock

Phage display-mediated immuno-polymerase chain reaction (PD-IPCR) is an ultrasensitive detection technology that combines the advantages of immuno-PCR and phage display. The phage particle, which displayed antibody fragments including single-chain fragment variable (scFv), variable domain of heavy-chain antibodies (VHH), and antigen-binding fragment (Fab) on the surface can be directly used in ...

Journal: :International journal of molecular medicine 2007
Irena Horwacik Dominik Czaplicki Katarzyna Talarek Aleksandra Kowalczyk Elzbieta Bolesta Danuta Kozbor Hanna Rokita

Aberrant glycosylation is a universal feature of cancer cells. There are quantitative and qualitative changes in expression of gangliosides observed in tumors of a neuroectodermal origin such as neuroblastoma, melanoma and astrocytoma. The presence of large amounts of GD2 ganglioside on neuroblastoma cells, as compared to normal cells, opens the possibilities to use the tumor-associated carbohy...

Journal: :Cancer research 2004
Victor I Romanov Terry Whyard Howard L Adler Wayne C Waltzer Stanley Zucker

Bone metastasis is the most frequent complication of prostate cancer (PC). Elucidation of the biological basis of this specificity is required for the development of approaches for metastatic inhibition. We investigated the possibility that the preferential attachment of PC cells to bone marrow endothelium (as opposed to endothelium from other organs) affects this specificity. We selected, from...

2013
Bo Tang Zhexu Li Dingde Huang Lei Zheng Qianwei Li

BACKGROUND/PURPOSE The VPAC1 receptor, a member of the vasoactive intestinal peptide receptors (VIPRs), is overexpressed in the most frequently occurring malignant tumors and plays a major role in the progression and angiogenesis of a number of malignancies. Recently, phage display has become widely used for many applications, including ligand generation for targeted imaging, drug delivery and ...

Multiple Sclerosis (MS) is a chronic neurological disease of the central nervous system (CNS), characterised by a cellular immune response in early stages and demyelination of the CNS later. Although the cause of MS is unknown, there is much evidence that points to MS as an autoimmune disease. To test the hypotheses that an Autoantigen is involved in MS, we screened a ?gt11 human foetal spinal ...

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