OBJECTIVE To describe atopic dermatitis (AD) management patterns in children ≤36 months old as reported by pediatricians, dermatologists, and allergists in the US. STUDY DESIGN A nationally-representative survey was administered to pediatricians (n = 101), dermatologists (n = 26), and allergists (n = 26). Main outcomes included referrals to health care professionals, suggested/ordered laborat...

Congenital or monogenic hyperinsulinism (HI) is a group of rare genetic disorders characterized by dysregulated insulin secretion and the most common cause persistent hypoglycemia in children. Knowledge normal glucose homeostasis allows for better understanding underlying pathophysiology hyperinsulinemic hypoglycemia, facilitating timely diagnosis management. The goal management to prevent cere...

Complex regional pain syndrome (CRPS) type I is a painful and disabling syndrome that is accompanied by physical changes in the affected extremity. It generally occurs after trauma, manifesting as pain that is out of proportion to the inciting event. Treatment of the disorder is difficult, with many patients being refractory to multiple pharmacologic regimens. Regional anesthetic techniques, in...

Melanoma cells exhibit numerous transcriptional cell states including developmental programs such as neural crest-like and pigmented melanocytic cells. These endow tumorigenic properties like sustained growth, immune evasion, therapy resistance, metastasis. Here, we use a zebrafish melanoma model to identify program linking the state dependence on lipid droplets, specialized organelle responsib...

BACKGROUND Obsessive-compulsive disorder is treated with exposure with response prevention (ERP) therapy, in which patients are repeatedly exposed to compulsive triggers but prevented from expressing their compulsions. Many compulsions are an attempt to avoid perceived dangers, and the intent of ERP is to extinguish compulsions. Patients failing ERP therapy are candidates for deep brain stimula...

Chimeric antigen receptor (CAR) T cells can produce durable remissions in hematologic malignancies that are not responsive to standard therapies. Yet the use of CAR T cells is limited by potentially severe toxicities. Early case reports of unexpected organ damage and deaths following CAR T-cell therapy first highlighted the possible dangers of this new treatment. CAR T cells can potentially dam...

Intensivists routinely administer glucocorticoids, which are potent anti-inflammatory, immune, metabolic, and adrenergic modulating compounds at physiologic and pharmacologic doses. Recent investigations report increasing recognition of relative or absolute adrenal insufficiency in critically ill patients and the impact of cortisol responsiveness as a predictor of outcome for the critically ill...