pharmacology

Objective: To explore the potential mechanism of Sini jia Renshen Decoction (SJRD) in treatment COVID-19 based on network pharmacology and molecular docking. Methods: The active compounds therapeutic targets SJRD were collected through Traditional Chinese Medicine Systems Pharmacology Database (TCMSP). Then a string database was used to build protein–protein interactions (PPI) between proteins,...

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Could NICE guidance on the choice of blood pressure lowering drugs be simplified?

2012

Reecha Sofat Juan P Casas Anthony M Grosso Brian N C Prichard Liam Smeeth Raymond MacAllister Aroon D Hingorani

Reecha Sofat specialist registrar in clinical pharmacology , Juan P Casas senior lecturer in epidemiology 2 , Anthony M Grosso honorary associate professor in clinical pharmacy 1 , Brian N C Prichard emeritus professor of clinical pharmacology , Liam Smeeth professor of clinical epidemiology , Raymond MacAllister professor of clinical pharmacology , Aroon D Hingorani professor of genetic epidem...

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A Philosophical Framework for Integrating Systems Pharmacology Models Into Pharmacometrics

2016

SB Duffull

The framework for systems pharmacology style models does not naturally sit with the usual scientific dogma of parsimony and falsifiability based on deductive reasoning. This does not invalidate the importance or need for overarching models based on pharmacology to describe and understand complicated biological systems. However, it does require some consideration on how systems pharmacology fits...

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