Three experiments were conducted to determine whether there is a causative relation between dietary glycine concentration and intestinal Clostridium perfringens growth in broiler chickens. Expt. 1 showed that glycine concentrations were higher (P < 0.05) in jejunum and ileum of birds fed fat-encapsulated glycine compared with crystalline glycine. In Expt. 2, 2 cages of 6 birds were assigned to ...

We examined the effect of ondansetron, an antagonist of type 3 serotonin receptors, on the whole cell response of freshly isolated hippocampal CA1 pyramidal neurons of neonatal and "mature" rats to glycine using the gramicidin perforated patch technique. Ondansetron depressed the current induced by subsaturating concentrations of glycine (IGly) in a concentration-dependent manner. The ondansetr...

1. Samples of portal venous and femoral arterial plasma and mesenteric lymph were collected from unanaesthetized rats before and during the intra-duodenal infusion of high concentrations (100 mmoljl) of glycine or glycine oligopeptides (up to and including tetraglycine). 2. There was a marked increase in the concentration of free glycine, and a small amount of diglycine was detected in all the ...

background and objective: microbial protein production can resolve one of the major world challenges, i.e. lack of protein sources. candida tropicalis growth was investigated to specify a medium to reach the highest cell proliferation and protein production. material and methods: fractional factorial design and the index of signal to noise ratio were applied for optimization of microbial protei...

These experiments were designed to investigate the defect in amino acid uptake in a D-serine-resistant mutant (WS) of Escherichia coli W that is deficient in the uptake of glycine. Under conditions in which there is insignificant metabolism of glycine (i.e. 0” under nitrogen), the wild type took up significant amounts of glycine, whereas the WS mutant did not equilibrate with the external glyci...

I . Rates of absorption of glycine and glycylglycine from a 300 mm jejunal segment were compared in vivo when those compounds were given alone or together to six Zambian African subjects who had no clinical evidence of malnutrition or of gastro-intestinal disease. Solutions containing (A) glycine (~oommol/l), (B) glycine (Ioommol/l)+glycylglycine (50 mmol/l), and (C) glycglglycinc (50 mmolil) w...

BACKGROUND Human fetal midbrain-derived neural progenitor cells (NPCs) may deliver a tissue source for drug screening and regenerative cell therapy to treat Parkinson's disease. While glutamate and GABA(A) receptors play an important role in neurogenesis, the involvement of glycine receptors during human neurogenesis and dopaminergic differentiation as well as their molecular and functional cha...

In the title compound, C(16)H(16)O(2)S, the central propenone group is almost planar (r.m.s. deviation = 0.009 Å) and subtends dihedral angles of 8.55 (8) and 16.22 (8)° to the 2-meth-oxy-phenyl and 2,5-dimethyl-thio-phene residues, respectively. The dihedral angle between the ring systems is 23.47 (5)°. In the crystal, mol-ecules are linked by weak C-H⋯π inter-actions and aromatic π-π stacking...

Glycine decarboxylase, tentatively called P-protein and considered a constituent of the glycine cleavage system, was purified to apparent homogeneity from chicken liver mitochondria. P-protein is a homodimer having a Mr = approximately 200,000 and consisting of identical subunits with Mr = approximately 100,000. Each subunit appears to contain an equimolar pyridoxal 5'-phosphate which is bound ...