catalytic and photocatalytic reactions of (2-chloroethyl) phenyl sulfide (2-ceps), a mimic of bis (2-chloroethyl)  sulfide (i.e. sulfur mustard) were studied on the surfaces of titanium oxide. tio2 nanoparticles (anatase, rutile and mixture of 80% anatase/20% rutile) along with bulk tio2 were tested as reactive sorbents for reaction of 2-ceps at room temperature (25±0.5°c). reactions were monit...

Several new and know 6-(4-substituted phenyl)-4-(4-substituted phenyl)-2-phenyl-6H-1,3-thiazine (or selenazine) (Z4B7, Z4D5, Z4B7' Z4D5') were prepared by the 1,4-Michael addition reaction of chalcone derivatives with thiobenzamide or phenylselenocarboxamide in basic medium (where chalcones was formed Claisen-Schimidt condensation aromatic aldehydes 4-substituted acetophenone presence sodium hy...

The mechanisms for the formation of N-substituted hydrazones by coupling alcohols and hydrazine, achieved sequential processes acceptorless dehydrogenation borrowing hydrogen, has been unveiled density functional theory (DFT) calculations. release water molecular hydrogen as subproducts, combined with Mn-PNN pincer based catalyst describe a green environment. Mechanistically, apart from describ...

Three bench-stable difluoromethylene phosphonate hydrazones were prepared from simple diethyl(difluoromethyl)phosphonate within two steps in good yields. The [3 + 2] cycloaddition reaction of these diazo precursors with aryl diazonium salts has been accomplished under metal-free conditions exclusive regioselectivity. This transformation provides practical access to a broad panel 2-aryl-2 H -tet...

The MDR-involved human GSTA1-1, an important isoenzyme overexpressed in several tumors leading to chemotherapeutic-resistant tumour cells, has been targeted by 2,2'-dihydroxybenzophenones and some of their carbonyl N-analogues, as its potential inhibitors. A structure-based library of the latter was built-up by a nucleophilic cleavage of suitably substituted xanthones to 2,2'-dihydroxy-benzophe...

Bis(p-tolyl) ketone p-tosylhydrazone (2) crystallized as three conformational polymorphs, forms 1-3, under different conditions. The crystal structure of form 1 has an N-H‚‚‚OdS dimer synthon, but forms 2 and 3 have no strong hydrogen bonds even though the molecule contains an SO2NH group. Polymorphs 1 and 3 are assigned as kinetic and thermodynamic forms on the basis of the criteria of lower e...

In Paper I of this series (1) a method was described for the paper chromatographic analysis of certain ketonic steroids as hydrazones formed with Girard’s Reagent T. When that technique was applied to the adrenal cortical hormones, however, certain deficiencies appeared. (a) The RI values of the individual steroid-Reagent T hydrazones were not sufficiently different to permit identification. (b...

Hydrazones derivatives of carbonyl compounds constitute an important class of biologically active compounds. Metal complexes of Schiff bases represent an important class of coordination compounds. Schiffs base containing hetero donar atom continue to provide the interesting facts in the fields of coordination chemistry. Literature studies on hydrazones have shown that these derivatives possess ...