Fatty acyl coenzyme A-glycerol 3-phosphate, fatty acyl coenzyme A-lysophosphatidic acid, fatty acyl coenzyme A-monoglyceride, and fatty acyl coenzyme A-diglyceride acyltransferase activities were found in a particulate fraction of broken cell preparations of Escherichiu coli. The synthesis of phosphatidic acid and lysophosphatidic acid catalyzed by these enzymes was demonstrated to be dependent...

Experimental studies reveal that the anionic lipid phosphatidic acid (POPA), non-phospholipid cholesterol, and cationic DOTAP inhibit gating of voltage-sensitive potassium (Kv) channels. Here, we develop a continuum electromechanical model to investigate interaction these lipids with ion channel. Our suggests that: (i) POPA may restrict vertical motion voltage-sensor domain through direct elect...

Polyamines with diamine structures of chain length longer than 3C were essential for the synthesis of phosphatidic acid (PA) from ricinoleoyl-CoA and lysophosphatidic acid (LPA) by the castor LPA acyltransferase reaction, suggesting that polyamines modulate enzyme affinity for the acyl-CoA substrate in vivo.