Acetate grown cells of Azotobacter, like sucrose grown cells (Stone and Wilson, 1952), are unadapted to the oxidation of succinic acid although possessing an enzyme system capable of oxidizing succinate. Hence the adaptation of these cells to succinic acid may be termed a functional change in the physiology of the organism. In contrast, glucose grown cells of Saccharomyces cerevisae are unadapt...