Statistical Learning Theory is commonly regarded as a sound framework within which we handle a variety of learning problems in presence of small size data samples. It has become a rapidly progressing research area in machine learning. The theory is based on real random samples and as such is not ready to deal with the statistical learning problems involving complex fuzzy random samples, which w...

Different methods have been experimented for processing and detecting forgery in digital images. Image forgery involves various activities like copy-move forgery, image slicing, retouching, morphing etc. In copy-move forgery a portion within the image is copied and pasted on another part of the same image, generally to conceal or enhance certain portions of the image. This paper proposes a copy...

The Kaplan-Yorke conjecture suggests a simple relationship between the fractal dimension of a system and its Lyapunov spectrum. This relationship has important consequences in the broad field of nonlinear dynamics where dimension and Lyapunov exponents are frequently used descriptors of system dynamics. We develop an experimental system with controllable dimension by making use of the Kaplan-Yo...

In this lecture we address some limitations of the analysis of Occam algorithms that limit their applicability. We first discuss the case where the target concept c is not in H which is known as the non-realizable case and as agnostic PAC learning. We then turn to the case where the number of examples m is fixed (i.e., we cannot ask for more examples as in the standard PAC model) and consider h...

Additional file for the article " CheS-Mapper 2.0 for Visual Validation of (Q)SAR models " We visually validate the effect of exchanging the descriptors used by a (Q)SAR algorithm. To this end, we select a subset of the Carcinogenic Potency Database (CPDB) [1] for various species. The database contains 86 compounds that have an activity value for hamster carcinogenicity assigned (active or inac...

UNLABELLED The drug classification scheme of the World Health Organization (WHO) [Anatomical Therapeutic Chemical (ATC)-code] connects chemical classification and therapeutic approach. It is generally accepted that compounds with similar physicochemical properties exhibit similar biological activity. If this hypothesis holds true for drugs, then the ATC-code, the putative medical indication are...

In our previous paper (Reshetnyak, Ya. K., and E. A. Burstein. 2001. Biophys. J. 81:1710-1734) we confirmed the existence of five statistically discrete classes of emitting tryptophan fluorophores in proteins. The differences in fluorescence properties of tryptophan residues of these five classes reflect differences in interactions of excited states of tryptophan fluorophores with their microen...

Purpose: The quality of education and research is one of the concerns that academic systems always strive to achieve. Undoubtedly, the existence of leading professors with appropriate scientific and ethical competencies is one of the effective fundamental factors in the quality of higher education systems. Methodology: The general purpose of the present study is to examine the dimensions of le...

Predicting protein function from structure remains an active area of interest, particularly for the structural genomics initiatives where a substantial number of structures are initially solved with little or no functional characterisation. Although global structure comparison methods can be used to transfer functional annotations, the relationship between fold and function is complex, particul...

One of the proposed mechanisms of homocysteine toxicity in human is the modification of proteins by the metabolite of Hcy, homocysteine thilolactone (HTL). Incubation of proteins with HTL has earlier been shown to form covalent adducts with ε-amino group of lysine residues of protein (called N-homocysteinylation). It has been believed that protein N-homocysteinylation is the pathological hallma...