Phytoestrogens are plant-derived polyphenols with a structure similar to human estrogens. The three main groups of phytoestrogens, isoflavones, ellagitannins, and lignans, are transformed into equol, urolithins, and enterolignans, respectively, by bacteria. These metabolites have more estrogenic/antiestrogenic and antioxidant activities than their precursors, and they are more bioavailable. The...

Phytoestrogens are a chemically diverse group of compounds made by plants that can have estrogenic effects in animals. Both tumorigenic and antitumorigenic effects have been reported. Although estrogens stimulate the growth of many breast tumors, there is a negative correlation between the incidence of breast cancer and the phytoestrogen-rich diet of certain Asian populations. To begin to resol...

We investigated the estrogenic activity of various environmental pollutants (xenobiotics), in particular the xenoestrogen o,p-DDT, and compared their effects with those of endogenous estrogens, phytoestrogens, and mycoestrogens on estrogen receptor binding capacity, induction of estrogen end products, and activation of cell proliferation in estrogen-sensitive human breast cancer cells in monola...

Some organochlorine pesticides and other synthetic chemicals mimic hormones in representatives of each vertebrate class, including mammals, reptiles, amphibians, birds, and fish. These compounds are called endocrine-disrupting chemicals (EDCs). Similarly, hormonelike signaling has also been observed when vertebrates are exposed to plant chemicals called phytoestrogens. Previous research has sho...

lating bone cell activities is central to understanding the etiology and treatment of postmenopausal osteoporosis. In the past few years, natural estrogen-like molecules, the phytoestrogens, have attracted attention for their potential roles in osteoporosis prevention and treatment. In contrast to the isoflavone-type phytoestrogens such as genistein, lignan-type phytoestrogens have rarely been ...

Phytoestrogens exist in edible compounds commonly found in fruits or plants. For long times, phytoestrogens have been used for therapeutic treatments against human diseases, and they can be promising ingredients for future pharmacological industries. Kaempferol is a yellow compound found in grapes, broccoli and yellow fruits, which is one of flavonoid as phytoestrogens. Kaempferol has been sugg...

1383-5866/$ see front matter 2011 Elsevier B.V. A doi:10.1016/j.seppur.2011.12.020 ⇑ Corresponding author. Tel.: +351 253 604 424; fa E-mail addresses: [email protected], so (S.I. Mussatto). Methanol, ethanol, and acetone at four different concentrations (90%, 70%, 50%, and 30% v/v) were used for extraction of phytoestrogens (nordihydroguaiaretic acid (NDGA), kaempferol, and quercetin) from...

BACKGROUND Epidemiologic studies have reported various results relating phytoestrogens to prostate cancer (PCa). The aim of this study was to provide a comprehensive meta-analysis on the extent of the possible association between phytoestrogens (including consumption and serum concentration) and the risk of PCa. METHODS Eligible studies were retrieved via both computer searches and review of ...

Proper and balanced nutrition is very important in prevention and treatment of chronic diseases. Many individuals modify their diet and/or take different nutraceuticals expecting to attain optimum health, extend their lifespan and prevent diseases such as cardiovascular, cancer, osteoporosis, obesity, or diabetes type II. Based on „Japanese phenomenon“ (Adlercreutz, 1998), numerous advertisemen...

OBJECTIVE Dietary phytoestrogens are promoted as alternatives to synthetic estrogens for hormone therapy, however, their effects on the reproductive axis have not been exhaustively studied in vivo. Female aromatase knockout mouse (ArKO) mice are estrogen-free, anovulatory, and have a block in folliculogenesis, hemorrhagic cysts, and development of Sertoli cells within their ovaries. The purpose...