We report the results of a series of chemical, EPR, ENDOR, and HYSCORE spectroscopic investigations of the mechanism of action (and inhibition) of GcpE, E-1-hydroxy-2-methyl-but-2-enyl-4-diphosphate (HMBPP) synthase, also known as IspG, an Fe(4)S(4) cluster-containing protein. We find that the epoxide of HMBPP when reduced by GcpE generates the same transient EPR species as observed on addition...

OBJECTIVE It was the aim of this study to develop models for the prediction of preeclampsia (PE) based on maternal characteristics and biophysical markers at 11-13 weeks' gestation in which gestation at the time of delivery for PE is treated as a continuous variable. METHODS This was a screening study of singleton pregnancies at 11-13 weeks including 1,426 (2.4%) cases that subsequently devel...

Page 4 PSG Request for Datamining Abstract Parkinson’s disease (PD) has many paradoxes. For example, although smoking is highly associated with cancer and cardiovascular disease, smoking is associated with a much lower risk of PD (which itself is associated with a lower occurrence of cardiovascular disease). Whereas the apolipoprotein E ε4 allele is associated with higher risk of Alzheimer’s di...

Infection with helminth parasites typically evokes a T helper 2-cell response in the mammalian host. Interleukin (IL)-4 and IL-13 are important in the rapid expulsion of parasitic nematodes, with the absence of either cytokine being compensated for by the other. However, the IL-4 and IL-13 common signaling molecule, signal transducer and activator of transcription 6 (STAT-6) appears to be manda...

A general linear singular boundary value problem dxi dt = Pi(t) · x3−i + qi(t) (i = 1, 2), xi(τk+)− xi(τk−) = Gi(k) · x3−i(τk) + hi(k) (i = 1, 2; k = 1, 2, . . .); li(x1, x2) = ci (i = 1, 2) is considered, where Pi ∈ Lloc(]a, b[ ,Rni×n3−i), qi ∈ Lloc(]a, b[ ,Ri), Gi : {1, 2, . . .} → Rni×n3−i , hi : {1, 2, . . .} → Ri , ci ∈ Ri , and li is a linear bounded operator (i = 1, 2). The singularity i...

Induction of the B7 family molecules by 12-O-tetradecanoyl phorbol 13-acetate (TPA) has been reported, however, the mechanism by which TPA up-regulates these molecules remains poorly understood. In this study, the expression of B7-DC, -H1, -H2, and -H3 in response to TPA was markedly induced in K562 cells. TPA also induced activation of ERK, p38 mitogen-activated protein kinase (MAPK), JNK, pho...

CONTEXT AND OBJECTIVE The presence of a certain degree of inflammation in the gut wall is now accepted in irritable bowel syndrome (IBS). Fecal calprotectin is considered to be a reliable test for detecting intestinal inflammation. Our aim was to assess the presence of inflammation in postinfectious IBS (PI-IBS), compared with non-postinfectious IBS (NPI-IBS). A secondary objective was to deter...

OBJECTIVE To reveal the incidence and clinical significance of mediastinal nodal metastases without N1-station nodal metastases ('skip-N2 metastases') in non-small cell lung cancer (NSCLC). METHODS A total of 450 NSCLC patients who underwent tumor resection with a systemic mediastinal nodal dissection were retrospectively reviewed. p53 status and proliferative activity represented as prolifer...

The ponderal index (PI) (g/cm3 X 100) was used to define the state of nutrition at birth of 47 light-for-date (LFD) term infants and to determine how intrauterine undernutrition influences growth during the first 6 months of postnatal life, at four age intervals: birth--4, 5--8, 9--12, 13--26 weeks. With the exception of one baby, each PI was less than 50th centile on the Miller and Hassanein s...

INTRODUCTION Package insert (PI) is a vital document accompanying a prescribed medication to provide information to the prescriber and end-user at a glance. Studies regarding PIs of Ayurvedic medicines in accordance with standard guidelines are lacking. AIM Present study was undertaken to evaluate PI of Ayurveda drugs. MATERIALS AND METHODS PIs of Ayurveda drugs were obtained from five rand...