fourteen patients with bilateral low frequency sensorineural hearing loss were found with disproportionate speech discrimination scores. these patients were submmitted to a comprehensive audiological, electrophysiological, neurological, and radiological battery of investigation. the results pointed to a lesion probably in the central auditory pathway.

acute myeloblastic leukemia is the most frequent cancer in adults and the patients have a wide range of sub-classes. hla dr negative cases represent one of the major immune-phenotypic classes.  hla-dr is routinely used to distinguish acute promyelocytic leukemia (apl) from other aml subclasses based on the immunophenotype. the tgf-b signaling pathway, as a critical regulator, guides different v...

Atherosclerosis has serious role in coronary arteries disease,so it is important to establish effective strategies for prevention or even treatment of atherosclerosis. Adiponectin, as one of the most abundant adipokines, has insulin sensitivity, anti-inflammatory and anti-atherogenic properties. Disturbed adiponectin actions through its receptor, (AdipoR1 and AdipoR2) may be involved in atheros...

Abstract Aim 1 - To compare the current standard of practice to existing guidelines and make appropriate changes. 2 set a clear pathway for referring patients ‘hot laparoscopic cholecystectomy’ pathway. 3 Avoid inappropriate booking Cholecystectomy who are not fulfilling criteria Hot Gall Bladder Pathway. 4 unnecessary delay in performing Laparoscopic patient with Acute Cholecystitis mild Bilia...

Objective(s):Cyclophosphamide (CP) toxicity on testis was hampered by squid ink polysaccharide (SIP) via restoration of antioxidant ability in our previous investigations. This study investigated roles of Nrf2/ARE signal pathway in testis of treated mice. Materials and Methods: Male Kunming mice were employed to undergo treatment with SIP and/or CP. Protein levels of Nrf2, keap-1, histone deac...

aflatoxins are secondary toxic metabolites produced by some aspergillus spp. particularly, aspergillus flavus and a. parasiticus that contaminate food and feed. the objective of this study was to evaluate the contamination of feedstuffs with aspergillus spp. and detect genes involved in the aflatoxin biosynthesis pathway of a. flavus and a. parasiticus isolates. a total of 110 cow feed samples ...

objective(s): the janus kinase-signal transducers and activators of transcription signaling pathway (jak/stat pathway) play an important role in proliferation of breast cancer cells. previous data showed that inhibition of stat3 suppresses the growth of breast cancer cells, but the associated mechanisms are not well understood. this study aims to investigate the effect and associated mechanisms...