نتایج جستجو برای: pick disease
تعداد نتایج: 1499420 فیلتر نتایج به سال:
تصمیمگیری در روابط عاشقانه مثل شروع یک دوره آشنایی، پیشنهاد ازدواج یا پایان دادن به یک رابطه میتواند عواقب درازمدت و مهمی داشته باشد. هدف پژوهش حاضر بررسی اثر بخشی آموزش قبل از ازدواج به شیوه برنامه آگاهی و انتخاب های بین فردی (PICK) بر تصمیم گیری دانشجویان مجرد بود. پژوهش حاضر نیمه آزمایشی با طرح پیش آزمون و پس آزمون با گروه کنترل بود. 36 دانشجوی مجرد بر اساس نمره یک انحراف معیار پایین ...
how to cite this article: tonekaboni sh. approach to npc disease. iran j child neurol. 2015 autumn;9:4(suppl.1): 7. pls see pdf.
performance of the GM-CSF affinity column used to isolate antibodies. If used repeatedly, is it possible that a proportion of high affinity anti–GM-CSF AAs from PAP sera used as a positive control would be retained on the GM-CSF column and released slowly during subsequent purifications of HC IgG? If PAP anti–GMCSF IgG contamination did occur, not only would it account for the immunoblot data g...
Impaired transduction of transforming growth factor-A signaling has recently been implicated in Alzheimer disease. Transforming growth factor-A signals are transduced by Smads, which are phosphorylated and translocated to the nucleus, where they initiate gene transcription. In Alzheimer disease, neurofibrillary tangles sequester phosphorylated Smad 2/3 (pSmad2/3) and reduce its nuclear transloc...
Niemann-Pick type C disease (NPC) is a rare and progressive genetic condition that is associated with an abnormal accumulation of lysosomal lipids in the body, which manifests as a variety of neurological symptoms that range greatly in severity. Management focuses largely on treating symptoms, but recent developments have led to disease-specific therapy that can slow or stabilise the progressio...
BACKGROUND The biological diagnosis of sphingolipidoses currently relies on the measurement of specific enzymatic activities and/or genetic studies. Lysosphingolipids have recently emerged as potential biomarkers of sphingolipidoses and Niemann-Pick type C in plasma. METHODOLOGY We developed a sensitive and specific method enabling the simultaneous quantification of lysosphingolipids by LC-MS...
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