نتایج جستجو برای: piperazin derivative
تعداد نتایج: 64343 فیلتر نتایج به سال:
Novel 1-(2-{3-/4-[(alkoxycarbonyl)amino]phenyl}-2-hydroxyethyl)-4-(2-fluorophenyl)-piperazin-1-ium chlorides (alkoxy = methoxy to butoxy; 8a-h) have been designed and synthesized through multistep reactions as a part of on-going research programme focused on finding new antimycobacterials. Lipophilic properties of these compounds were estimated by RP-HPLC using methanol/water mobile phases with...
The deletion of Phe-508 (F508del) constitutes the most prevalent cystic fibrosis-causing mutation. This mutation leads to cystic fibrosis transmembrane conductance regulator (CFTR) misfolding and retention in the endoplasmic reticulum and altered channel activity in mammalian cells. This folding defect can however be partially overcome by growing cells expressing this mutant protein at low (27 ...
Impaired transmission through glutamatergic circuits has been postulated to play a role in the underlying pathophysiology of schizophrenia. Furthermore, inhibition of the N-methyl-d-aspartate (NMDA) subtype of ionotropic glutamate receptors (NMDAR) induces a syndrome that recapitulates many of the symptoms observed in patients with schizophrenia. Selective activation of metabotropic glutamate r...
The present study examined the effects of two novel dopamine D3 receptor compounds, NGB 2904 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide], an antagonist, and CJB 090 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], a partial agonist, in two models of cocaine abuse in rhesus monkeys. To establish a dose range and time course of effec...
in this paper, we establish the existence and uniqueness result of the linear schrodinger equation with marchaud fractional derivative in colombeau generalized algebra. the purpose of introducing marchaud fractional derivative is regularizing it in colombeau sense.
In the title compound, C(16)H(21)N(3)O(3), the piperazine ring adopts a chair conformation, with its N-C bonds in pseudo-equatorial orientations. In the crystal, mol-ecules are linked by O-H⋯N hydrogen bonds, generating C(5) chains propagating in [101]. Weak aromatic π-π stacking inter-actions also occur [centroid-centroid separation = 3.899 (1) Å].
توسیع تعدادی از نامساوی های چند جمله ای در مشتق قطبی
In the title compound, C12H16N2O2, the piperazine ring has a chair conformation. The dihedral angle between the mean planes of the benzene ring and the acetyl group is 48.7 (1)°. In the crystal, mol-ecules are linked via O-H⋯O hydrogen bonds, forming chains propagating along [010].
Abstract. We prove that for every function f : X → Y , where X is a separable Banach space and Y is a Banach space with RNP, there exists a set A ∈ Ã such that f is Gâteaux differentiable at all x ∈ S(f) \ A, where S(f) is the set of points where f is pointwise-Lipschitz. This improves a result of Bongiorno. As a corollary, we obtain that every K-monotone function on a separable Banach space is...
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