نتایج جستجو برای: piperazine derivative
تعداد نتایج: 65723 فیلتر نتایج به سال:
In the cation of the title salt, C9H13N2O2 (+)·C7H3N2O6 (-), the piperazine ring adopts a slightly distorted chair conformation. Twofold rotational disorder is exhibited by the furan ring in a 0.430 (4):0.570 (4) ratio. In the crystal, N-H⋯O hydrogen bonds link the ions into chains along [010]. Additional weak C-H⋯O inter-actions are observed, leading to a supra-molecular layer parallel to (011).
Novel acrylamide and methacryloyl carrying piperazine-dihydrofuran derivatives (3a-p) were designed obtained from radical cyclizations of unsaturated piperazine (1a-f) with 1,3-dicarbonyl compounds (2a-c) mediated by Mn(OAc)3. Obtained characterized spectroscopic methods. In vitro AChE inhibitory activites 3a-p evaluated against (Acetylcholinesterase) Ellman method test results showed that 3a, ...
The present study was undertaken to investigate antichelmintic activity of petroleum ether, chloroform, ethanol and aqueous extract of the stem bark of Bridelia retusa S. on adult African night crawlers (Eudrilus euginae) earthworms due to its anatomical and physiological similarity with the intestinal roundworm parasites of human being. Antihelmintic activity was investigated at 50 mg/ml for a...
A new series of 6-substituted-4-methyl-3-(4-arylpiperazin-1-yl)cinnolines 8-10 were synthesized as potential antifungal agents via intramolecular cyclization of the respective 1-(2-arylhydrazono)-1-(4-arylpiperazin-1-yl)propan-2-ones 5-7, mediated by polyphosphoric acid (PPA). The amidrazones themselves were synthesized via direct interaction of the appropriate hydrazonoyl chlorides 4a-d with t...
A series of substituted heteroaromatic piperazine and piperidine derivatives were found through virtual screening based on the structure of human enterovirus 71 capsid protein VP1. The preliminary biological evaluation revealed that compounds 8e and 9e have potent activity against EV71 and Coxsackievirus A16 with low cytotoxicity.
Spectrophotometric method for determination of cu(II) in the trace quantities was developed by using piperazine dithiocarbamate as ligand in ammonium chloride-ammonium hydroxide medium at pH -9.5. The procedure developed was applied for the estimation of cu(II) in microgram quantities in the water samples and the method developed was found to be simple and sensitive. Spectrophotometry is one of...
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