New psychoactive substances (NPS) are a heterogeneous and rapidly evolving class of molecules available on the global illicit drug market (e.g smart shops, internet, "dark net") as a substitute for controlled substances. The use of NPS, mainly consumed along with other drugs of abuse and/or alcohol, has resulted in a significantly growing number of mortality and emergency admissions for overdos...

The physiopathology of non-insulin-dependent diabetes mellitus is associated with a dysfunction in the regulation of insulin secretion. The alpha 2-adrenoceptors have been reported to be involved in this alteration, although alpha 2-antagonists containing an imidazoline ring may stimulate insulin secretion independently of alpha 2-adrenoceptor blockage. Recently, a new "imidazoline-binding site...

Many organic sulfones have been shown to possess antibacterial, antimalarial, anthelmintic, antilepral, antineoplastic, anti-inflammatory and antidiabetic acitivities. These sulfones are commonly prepared from sodium benzenesulfinate 1-0 which plays an important role in organic synthesis. However the application of 1-0 in solid-phase synthesis has received relatively less attention. This projec...

Neuropeptide S (NPS) was identified as the endogenous ligand of an orphan receptor now referred to as the NPS receptor (NPSR). In the frame of a structure-activity study performed on NPS Gly5, the NPSR ligand [D-Cys(tBu)]NPS was identified. [D-Cys(tBu)]NPS up to 100 M did not stimulate calcium mobilization in human embryonic kidney (HEK) 293 cells stably expressing the mouse NPSR; however, in a...

•Efficient three-component assembly of sulfondiimidamides; new analogs sulfonamides•Use unsymmetrical sulfurdiimide reagents is key to success the synthesis•Broad variation at all three nitrogen atoms and carbon substituent•Preparation enantiomerically enriched, chiral sulfur, examples A functional group an arrangement that defines topology reactivity a molecule. The ability modify these two pa...

•Unified solution to decarboxylative cross-nucleophile coupling reactions•Photoactive Fe(III) carboxylates + Fe(III)-mediated oxidation•Fe(III) salts are non-toxic, earth abundant, and low cost•Direct formation of C–C, C–O, C–S, C–N bonds without prefunctionalization Carboxylic acids valuable chemical building blocks because they widely available with significant structural diversity. Decarboxy...

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s: (*Denotes student presenting poster) Biochemistry and Metabolism 1. Identification of local and cross-chromosomal biosynthetic gene clusters in filamentous fungi using gene expression data. Mikael R. Andersen 1 , Jakob B. Nielsen 1 , Andreas Klitgaard 1 , Lene M. Petersen 1 , Tilde J. Hansen 1 , Lene H. Blicher 1 , Charlotte H. Gottfredsen 2 , Thomas O. Larsen 1 , Kristian F. Nielsen 1 , Uff...