Atherosclerosis is the underlying pathology for cardiovascular disease. The preventive effects of tocotrienol-enriched mixed fraction (TEMF) on atherogenesis remains unclear. Objective: To investigate TEMF supplementation early and established atherosclerosis. Methods: Twenty New Zealand white rabbits were divided into (n=10) placebo groups. Treatments given by oral gavage 8 weeks followed 1% h...

INTRODUCTION This analysis was conducted to assess the tolerability, safety, and efficacy of brivaracetam (BRV) for adjunctive treatment of focal (partial-onset) seizures in patients aged ≥65 years. METHODS Safety/tolerability and efficacy data for patients aged ≥65 years were pooled from three randomized, double-blind, placebo-controlled, fixed-dose Phase III studies (NCT00490035, NCT0046426...

AIMS Two multicentre, randomized, double-blind, placebo-controlled Phase II studies assessed the safety and efficacy of the oral protease-activated receptor 1 (PAR-1) antagonist E5555 in addition to standard therapy in Japanese patients with acute coronary syndrome (ACS) or high-risk coronary artery disease (CAD). METHODS AND RESULTS Patients with ACS (n = 241) or high-risk CAD (n = 263) rece...

3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (statins), are effective serum cholesterol-lowering agents which also have anti-inflammatory properties. The objective of this study was to evaluate the effect of atorvastatin on bronchial hyperresponsiveness. Adult patients (age 14 to 65 years) with bronchial hyperresponsiveness (BHR) diagnosis based on the spirometry with methacholine challe...

This study was conducted to evaluate the long-term effects of in ovo injection of nano-silver, thyme and savory extracts in broiler breeder eggs on growth performance, lymphoid organ weights, immune and blood parameters and bone mineral concentration of broiler chicks. A total of 560 fertilized broiler breeder eggs were divided into 7 groups. On d 5 of incubation, eggs were treated with the fol...

OBJECTIVE The aim of this study was to assess the efficacy and safety of adalimumab (ADA), a recombinant human monoclonal antibody against tumour necrosis factor α (TNF), for the induction of clinical remission in anti-TNF naïve patients with moderately to severely active ulcerative colitis. METHODS This 8-week, multicentre, randomised, double-blind, placebo-controlled study (NCT00385736), co...

Introducción: El aumento de la prevalencia diabetes mellitus implica un desafío importante para salud pública e impulsa búsqueda nuevas estrategias terapéuticas en medicina tradicional. Objetivo: Determinar el efecto del Cinnamomum zeylanicum Blume cultivado Perú sobre glicemia ratones con experimental. Materiales y métodos: Estudio experimental, preclínico, analítico, prospectivo. Se formaron ...

A randomised, double-blind, placebo-controlled, withdrawal clinical trial was conducted of prednisone <5 mg/ day versus placebo in 31 patients with rheumatoid arthritis (RA). These patients had been treated with long-term 1-4 mg/day of prednisone, 22 with 3 mg/day, in usual clinical care at a single academic clinical setting. Stable clinical status over 12 weeks prior to screening for the trial...

BackgroundPropranolol hydrochloride is a nonselective beta-adrenergic antagonist that has known activity in the myometrium. Small trials have shown propranolol decreases duration of induced labor, although those studies are limited by methodological variability.ObjectiveOur objective was to determine whether addition single dose induce labor nulliparous women would decrease total time vaginal d...

INTRODUCTION Current smoking cessation guidelines recommend setting a quit date prior to starting pharmacotherapy. However, providing flexibility in the date of quitting may be more acceptable to some smokers. The objective of this study was to compare varenicline 1 mg twice daily (b.i.d.) with placebo in subjects using a flexible quit date paradigm after starting medication. METHODS In this ...