Impetigo herpetiformis (IH) is a rare pustular dermatosis with unknown aetiology, typically occurring during pregnancy. Based upon a similar clinical and histological presentation, i.e. spongiform accumulation of polymorphonuclear leucocytes in the stratum corneum, several authors consider IH as a variant of generalized pustular psoriasis (GPP), while others state that IH is a separate entity. ...

Psoriasis merupakan penyakit radang kulit kronis dengan dasar genetik yang kuat. Berdasarkan tipenya, psoriasis dibagi menjadi plak (psoriasis vulgaris), gutata, pustulosa generalisata/lokalisata, inversa, dan eritroderma psoriatika. Manajemen mempertimbangkan tingkat keparahan penyakit. Acitretin, cyclosporine, methotrexate, infliximab terapi lini pertama untuk pustular generalisata. Adalimuma...

BACKGROUND Biologic therapies such as adalimumab, a tumour necrosis factor antagonist, are safe and effective in the treatment of moderate to severe chronic plaque psoriasis. OBJECTIVES To compare a biologic agent with methotrexate, a traditional systemic agent, to define clearly the role of biologics in psoriasis. METHODS Patients with moderate to severe plaque psoriasis were randomized to...

The prevalence of skin pain and the molecular mechanisms responsible for pain in psoriasis remain unclear. This study assessed skin pain in 163 patients (98 males, 65 females, range 18-81 years) with plaque psoriasis, evaluating: the subjective/objective features of this symptom compared with clinical severity of the disease; and the role of interleukin (IL)-33, (involved in both psoriasis and ...

A prospective cross-sectional study was done between December 2007 and June 2009 in the skin clinic, Sarawak General Hospital, to determine the clinical characteristics of 138 Sarawakian natives with a clinical diagnosis of psoriasis. Women made up 50.7% and the mean age of the patients was 45.2 years. Of the group, 94.2% had chronic stable plaque psoriasis, 86.9% had a body surface area involv...

Investigation of Candida yeast prevalence in patients with psoriasis has been performed with the aim of determining their possible role as a trigger factor in the pathogenic process of this disease. The purpose of our study was to investigate the prevalence of Candida species on the skin of intertriginous areas and psoriasis lesions as well as the prevalence of Candida species in the stool of p...

Psoriasis is a common, chronic, immune mediated, inflammatory disease of skin characterized by red patches enclosed with white scales and affects 2-3% of people in the world. Topical therapy, phototherapy, and systemic therapy were employed for management of disease from many last decades. However, long term uses of these agents are associated with unwanted effects and toxicities. Recently, Ito...

CYCLOSPORINE (CyA) has been shown to be effective in a variety of human autoimmune diseases. including psoriasis, nephrotic syndrome, type I diabetes, and sight-threatening uveitis. 1 Its potential side effects include nephrotoxicity, diabetogenicity, and neurotoxicity. Several studies (see elsewhere in this symposium) have shown that FK 506 prevents or suppresses autoimmune disorders in experi...