Removal of the corpuscles of Stannius (STX) in the freshwater European eel causes a marked increase in the concentrations of blood ionic calcium and protein-bound calcium. The hypercalcaemia peaks 20 days after STX and lasts at least another 20 days. In stanniectomized eels hypocalcin decreased both blood ionic and total calcium concentrations. The reduction of plasma total calcium concentratio...

How are calcium levels increased within cells? Increases in intracellular calcium arise through either calcium influx across the plasma membrane or release from intracellular calcium stores, which is usually either the endoplasmic reticulum (ER) or, in muscle, the sarcoplasmic reticulum (SR). Release of calcium from the ER/SR is activated by a variety of second messengers, such as inositol 1,4,...

Prothrombin time can be measured roughly on whole blood as in neonates, but is more commonly measured from plasma. Blood is taken into a vacutainer containing liquid citrate. Citrate acts as an anticoagulant by consuming all the calcium in the sample. The blood is mixed and centrifuged to separate blood cells from the plasma. The plasma is placed in a coagulation machine which takes a sample of...

Formation of an immunological synapse (IS) between APC and T cells activates calcium entry through ORAI channels, which is indispensable for T cell activation. Successful proliferation and maturation of naive T cells is possible only if premature inactivation of ORAI channels is prevented. Although it is undisputed that calcium entry through ORAI channels is required for T cell function, it is ...

OBJECTIVE Primary hyperparathyroidism (pHPT) is characterised by increased parathyroid hormone (PTH) secretion and consequently increased plasma calcium. During the last few decades parathyroid scintigraphy (PS), is applied in almost all patients with pPHT before surgery and specifically before minimally invasive parathyroidectomy. The aim of this study was to find the best cut-off levels of to...

A 64-year-old woman had normal serum calcium and plasma parathyroid hormone levels, despite an extremely high plasma parathyroid hormone-related protein (PTHrP) level. She underwent medical screening at our hospital and several neck tumors were detected by ultrasonography. After surgical resection of these tumors, her plasma PTHrP level was normalized. Histological examination showed that the r...

the in vitro dissolution of plasma-sprayed hydroxyapatite (pha) coatings with different characteristics, produced by various spraying conditions, in a tris-buffered solution at ph 7.4 was experimentally studied through the measurement of calcium ions release with inductively coupled plasma atomic emission spectroscopy (icp-aes), and then modeled. three coating characteristics, the crystallinity...

BACKGROUND Plasma exchange is used in the treatment of diseases mediated by pathogenic circulating proteins, or for transplant desensitization. Its non-targeted nature results in the depletion of physiologically important molecules, and it is often complicated by hypocalcaemia. AIM To determine the effects of plasma exchange on vitamin D binding protein (DBP) and associated vitamin D metaboli...

The vasodilator effect of local hypercapnic acidosis, produced by intra-arterial infusion of an acid buffer solution consisting of a mixture of glycine and hydrochloric acid, in the perfused hind limb and in the perfused gastrocnemius muscle of anesthetized dogs was examined at normal plasma calcium concentration and during elevation of the plasma calcium concentration produced by intra-arteria...