Recent studies have demonstrated that psychotropic drugs such as reserpine and chlorpromazine cause a significant increase in plasma human prolactin (hPRL) levels, frequently inducing galactorrhea (Frantz et al., 1972). Chlorpromazine is now commonly used as a means of stimulating hPRL secretion in man (Friesen et al., 1972; Turkington, 1972). Borenstein et al. (1968) first reported that galact...

background:the utility and efficacy of novel materials in tissue regeneration and antimicrobial therapy are contingent upon the employment of either blood derivatives rich in platelets or platelet-poor-plasma (ppp). this effect is largely mediated by the increased or decreased concentration of platelets in the plasma. the current study aimed to analyze and evaluate the impact of platelet-rich (...

background and objectives: biomaterials are widely used in medical devices such as urinary catheters. one of the main problems associated with long term using of the urinary catheters is biofilm formation on their surfaces. many techniques have been presented to reduce the biofilm formation. one of the most revolutionary techniques allowing such surface fictionalization is plasma surface modific...

phenylazo and benzothiazolylazo derivatives of trifluoroacetylacetone andhexafluoroacetylacetone have been synthesized and characterized. analytical and spectral datarevealed the existence of phenylazo derivatives in the intramolecularly hydrogen-bonded ketohydrazoneform while the benzothiazolylazo derivatives in the azo-enol form. the monobasicbidentate coordination of the phenylazo derivative...

The cytochrome P-450 (CYP)3A4-mediated metabolism of diclofenac is stimulated in vitro by quinidine. A similar effect is observed in incubations with monkey liver microsomes. We describe an in vivo interaction of diclofenac and quinidine that leads to enhanced clearance of diclofenac in monkeys. After a dose of diclofenac via portal vein infusion at 0.055 mg/kg/h, steady-state systemic plasma d...

Plants are rich in secondary metabolites, which often useful as a relevant source of nutraceuticals. Quercetin (QUE) is flavonol aglycone able to bind Transthyretin (TTR), plasma protein that under pathological conditions can lose its native structure leading fibrils formation and amyloid diseases onset. Here, the dual nature five quercetin 3-O-glycosylated derivatives, isolated from different ...

Industrial hemp is a multi-use crop that has been widely cultivated to produce fibers and nutrients, such as protein, dietary fiber, minerals, unsaturated fatty acids, which make them good fortifying component in food production. The antioxidant capability of oils reported. In the current study, for evaluating activity commercial oil "Annabis BIO" derived from certified industrial seeds without...

Metronidazole and it’s derivatives are drugs that have both antiprotozoal and anti bacterial effect.The reproductive toxicity of metronidazole has been shown in some studies. To investigate the effect of metronidazole on spermatogenesis in adult male rats, this study was designed. Eighteen wistar male rats (70-90days old) were randomly divided into three groups. Animals in group I (Control grou...

0