نتایج جستجو برای: platinum compounds
تعداد نتایج: 246783 فیلتر نتایج به سال:
A SERIES OF PT(LL) COMPLEXES WITH ANTITUMOR PROPERTIES: [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]PtL(2) (meso-1-PtL(2)) and [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]PtL(2), [2L=2Cl-,2I-,SO(4) (2)-; halo = F (erythro-8-PtL(2)),halo = Cl (erythro-9-PtL(2))] has been modelled by molecular mechanics (MM). The MM calculations were carried out f...
Heparan sulfate is identified as a ligand receptor for polynuclear platinum anti-cancer agents through sulfate cluster binding. We present a new biological role for platinum and coordination compounds and a new target for metal-based drugs while presenting a new chemotype for heparanase and growth factor inhibition through modulation (metalloshielding) of their interactions. Masking of extracel...
Resistance to platinum-based chemotherapy develops in the majority of patients with epithelial ovarian cancer (EOC). Platinum compounds form electrophilic intermediates that mediate DNA cross-linking and induce double-strand DNA breaks. Because the cellular response to electrophilic xenobiotics is partly mediated by Keap1-Nrf2 pathway, we evaluated the presence of Kelch-like ECH-associated prot...
A new ruthenium(ii) polypyridyl-platinum(ii) diethynyl triad containing 3-ethynylphenanthroline linked by platinum(ii) bis-tributylphosphine organometallics, Ru(ii)-Pt(ii)-Ru(ii), and platinum(ii) bis-ethynylphenanthroline complex has been prepared. The ruthenium(ii)-metal triads, Ru(ii)-M-Ru(ii) (M = Pt(ii) and Au(i)), showed typical MLCT absorption bands and a lowest energy pi-pi* absorption ...
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