PURPOSE Recently, the neurotrophin-4 (NTF4), VAV2 and VAV3 genes have been implicated in primary open-angle glaucoma (POAG) in the European and Japanese populations, respectively. This study was conducted to determine their involvement in an Indian population with POAG and primary angle-closure glaucoma (PACG). METHODS The entire NTF4 gene and the POAG-associated SNPs rs2156323 (VAV2) and rs2...

This research examines the timeline of discovery and Primary Open-Angle Glaucoma (POAG). By reviewing literature on genetic molecular mechanisms, we aim to emphasize a long-term treatment solution (iSTENT) mitigate intraocular pressure (IOP) related POAG etiology disease progression. is multifactorial, autosomal dominant, adult-onset eye wherein optic nerve cells become damaged due buildup exce...

Glaucomatous optic neuropathy (GON) associated with different forms of glaucoma and chronic ocular hypertension (cOHT) is characterized by progressive loss retinal ganglion cells their axons in the nerves that project to brain transmit visual information. The resultant thinning cause peripheral vision, which if not halted or slowed, can lead irreversible blindness. Whilst precise triggering ins...

Glaucoma is the leading cause of irreversible blindness globally, with Primary open angle glaucoma (POAG) being commonest subtype. POAG characterized by an increase in intraocular pressure (IOP), to optic nerve damage and subsequent visual field defects. Despite clinical burden this disease poses, current therapies aim reduce IOP rather than targeting underling pathogenesis. Although pathogenes...

To evaluate corneal hysteresis (CH), acquired with ocular response analyzer (ORA), as a risk factor for glaucoma progression in early-stage primary open-angle (POAG). In historical cohort study, patients diagnosed 2011 POAG according to the Hodapp, Parrish and Anderson classification modified Octopus perimetry followed up until glaucomatous development; otherwise, observations were censored Oct...

Oral form of citicoline, a nootropic and neuroprotective drug in use for almost five decades, recently was pronounced a food supplement in both USA and EU. The idea of adding citicoline to topical treatment of primary open angle glaucoma (POAG) aimed at decreasing intraocular pressure (IOP) appeared as a logical consequence of accepting neurodegenerative character of this disease. Experimental ...

Untreated primary open angle glaucoma (POAG) is a blinding optic neuropathy. Timely medical or surgical treatment is eVective in slowing the rate of optic nerve damage and delaying the onset of visually disabling field loss, but treatment is only eVective in prevention, and there is as yet no means of reversing established axon loss. In the United Kingdom, around 250 000 people suVer from POAG ...

PURPOSE To investigate the phenotype of primary open-angle glaucoma (POAG) in Brazilian families with mutation in exon 3 of TIGR/MYOC. METHODS Seventy-eight POAG patients with a positive family history and eighteen unrelated patients with POAG were screened by automated DNA sequencing for mutations in exon 3 of the TIGR/MYOC gene. The pedigrees of POAG patients with mutations that lead to ami...

PURPOSE Primary open angle glaucoma (POAG) is the most common type of glaucoma. Among the POAG genes identified so far, myocilin (MYOC) is the most frequently mutated gene in POAG patients worldwide. The MYOC Gln48His mutation is unique among Indian POAG patients. This mutation has not been observed in some populations within India and in other populations worldwide. The objectives of this work...

BACKGROUND A noninferiority trial was conducted to evaluate the efficacy of a single evening dose of fixed-combination latanoprost 50 μg/mL and timolol 0.5 mg/mL (Xalacom®; LTFC), in Chinese patients with primary open-angle glaucoma (POAG) or ocular hypertension (OH) who were insufficiently controlled on β-blocker monotherapy or β-blocker-based dual therapy. METHODS This 8-week, randomized, o...