Most tumors are epithelial-derived, and although disruption of polarity and aberrant cellular junction formation is a poor prognosticator in human cancer, the role of polarity determinants in oncogenesis is poorly understood. Using in vivo selection, we identified a mammalian orthologue of the Drosophila polarity regulator crumbs as a gene whose loss of expression promotes tumor progression. Im...

In sentiment analysis, polarity shifting means shifting the polarity of a sentiment clue that expresses emotion, evaluation, etc. Compared with other natural language processing (NLP) tasks, extracting polarity shifting patterns from corpora is a challenging one because the methods used to shift polarity are flexible, which often invalidates fully automatic approaches. In this study, which aime...

Planar cell polarity (PCP) proteins form polarized cortical domains that govern polarity of external structures such as hairs and cilia in both vertebrate and invertebrate epithelia. The mechanisms that globally orient planar polarity are not understood, and are investigated here in the Drosophila wing using a combination of experiment and theory. Planar polarity arises during growth and PCP do...

Planar cell polarization represents the ability of cells to orient within the plane of a tissue orthogonal to the apical basal axis. The proper polarized function of multiciliated cells requires the coordination of cilia spacing and cilia polarity as well as the timing of cilia beating during metachronal synchrony. The planar cell polarity pathway and hydrodynamic forces have been shown to inst...

We introduce the task of word and phrase-level polarity annotation for German as part of an attempt to develop a compositional theory of clause-level polarity determination. Thus, annotations should give access to the nested building blocks, the structural strata of polarity composition. Therefore and in contrast to existing polarity-tagged corpora, we annotate not exclusively on the basis of s...

The polarity shift problem is amajor factor that affects classification performance ofmachinelearning-based sentiment analysis systems. In this paper, we propose a three-stage cascade model to address the polarity shift problem in the context of document-level sentiment classification. We first split each document into a set of subsentences and build a hybrid model that employs rules and statis...

Electrophysiological studies of symmetry have found a difference wave termed the Sustained Posterior Negativity (SPN) related to the presence of symmetry. Yet the extent to which the SPN is modulated by luminance-polarity and colour content is unknown. Here we examine how luminance-polarity distribution across the symmetry axis, grouping by luminance polarity, and the number of colours in the s...

An alanine carrier protein was isolated from membranes of the thermophilic bacterium PS3 using ion exchange column chromatography followed by high performance liquid chromatography with a hydroxylapatite column. The final preparation consisted of a single polypeptide, with Mr = 42,500, as estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A polarity index of 33% was calcula...

In the developing mammalian brain, differentiating neurons mature morphologically via neuronal polarity programs. Despite discovery of polarity pathways acting concurrently with differentiation, it's unclear how neurons traverse complex polarity transitions or how neuronal progenitors delay polarization during development. We report that zinc finger and homeobox transcription factor-1 (Zeb1), a...