نتایج جستجو برای: poloxamer

تعداد نتایج: 717  

Golnar Dorraj, Hamid R. Moghimi

Preparation and characterization of thermoresponsive in-situ forming poloxamer hydrogel for controlled release of Nile red-loaded solid lipid nanoparticles. Nanoparticles (NPs) are cleared rapidly from systemic circulation and do not provide sustained action in most cases. To solve this problem, this investigation introduces an erodible in-situ forming gel system as potential vehicles for prolo...

The present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (PA) that can be used for the preparation of immediate release pellets formulation. Two commercially available grades poloxamer 188 (P 188) and poloxamer 407 (P 407) were selected, and solid dispersions (SDs) conta...

The present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (PA) that can be used for the preparation of immediate release pellets formulation. Two commercially available grades poloxamer 188 (P 188) and poloxamer 407 (P 407) were selected, and solid dispersions (SDs) conta...

2014
Juscemácia Araujo Daniele Araujo

The use of poloxamers (PL) have been one of the most widely strategies used for drug delivery systems. The copolymer Poloxamer 407 is a non-ionic surfactant consisting of polioxyethylene (POE) and polioxypropylene (POP) that has many pharmaceutical applications due to its thermoreversible properties. PL are biocompatible and for this reason, are very attractive as carrier systems for administra...

Journal: :iranian journal of pharmaceutical research 0
golnar dorraj department of pharmaceutics and nanotechnology, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. hamid reza moghimi department of pharmaceutics and nanotechnology, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran.

abstractvarious nanoparticles have been investigated as novel drug delivery systems, including solid lipid nanoparticles (slns). due to their rapid clearance from systemic circulation, nanoparticles do not provide sustained action in most cases. different strategies have been employed to overcome this problem. in this direction, the present study introduces erodible in-situ forming gel systems ...

Journal: :iranian journal of pharmaceutical sciences 0
golnar dorraj department of pharmaceutics and nanotechnology, school of pharmacy, shahid beheshti university of medical sciences, po box: 14155-6153, tehran, iran. hamid r. moghimi department of pharmaceutics and nanotechnology, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. pharmaceutical sciences research center, shahid beheshti university of medical sciences, tehran, iran.

preparation and characterization of thermoresponsive in-situ forming poloxamer hydrogel for controlled release of nile red-loaded solid lipid nanoparticles. nanoparticles (nps) are cleared rapidly from systemic circulation and do not provide sustained action in most cases. to solve this problem, this investigation introduces an erodible in-situ forming gel system as potential vehicles for prolo...

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