A variety of lactic acid bacteria were screened for their ability to produce folate intracellularly and/or extracellularly. Lactococcus lactis, Streptococcus thermophilus, and Leuconostoc spp. all produced folate, while most Lactobacillus spp., with the exception of Lactobacillus plantarum, were not able to produce folate. Folate production was further investigated in L. lactis as a model organ...

In 1944 Kohn and Liversedge (1) showed that tissue suspensions or slices incubated aerobically produce a compound which will condense with either p-aminobenzoic acid (PAB) to give a yellow color or with thiobarbituric acid to give an orange-red color. Brain is the most active tissue, liver next, and other tissues show some activity. Subsequently, Bernheim et al. (2) found that washed brain susp...

The elucidation of the structure of pteroylglutamic acid (PGA) (Lactobacillus casei factor, vitamin B,) has shown that p-aminobenzoic acid (PABA) is a component of the PGA molecule (1). Since earlier work has treated PABA and PGA as distinct growth factors for bacteria (2), it is now necessary to study the relationship in the utilization of these substances by bacteria. It has been shown that m...

In two previous reports, it was shown that cocarboxylase and p-aminobenzoic acid counteract the inhibitory effect of sulfathiazole on yeast and bacterial carboxylases. Whereas cocarboxylase brings about this effect without exercising any inhibitory action on carboxylase, p-aminobenzoic acid exercises the antagonistic action to sulfathiazole while maintaining a certain degree of inhibitory effec...

Pantothenic acid, a portion of the coenzyme A molecule (l), must be supplied in the diet for normal acetylation of p-aminobenzoic acid (PAB) (2) and of sulfanilamide (3) by the rat. Only at certain test levels of PAB, however, is pantothenate deficiency reflected by decreased acetylation (4). The present communication extends the study of the relation between acetylation and size of dose over a...

The charge distribution in a molecule is crucial in determining its physical and chemical properties. Aminobenzoic acid derivatives are biologically active small molecules, which have two possible protonation sites: the amine (N-protonation) and the carbonyl oxygen (O-protonation). Here, we employ gas-phase infrared spectroscopy in combination with ion mobility-mass spectrometry and density fun...

Protected L-homoDMDP en-8 and its C-6 epimer en-7 were prepared through two different pathways starting from the vinylpyrrolidine en-9. Based on the NMR and X-ray analysis, the stereochemistry of homoDMDP at C-6 was confirmed to be consistent with reported data. Compounds en-7 and en-8 are general intermediates for the synthesis of a series of 6-C-alkylated DMDP-related natural products, such a...

p-Aminomethylbenzenesulphonamide (I) was first described by Miller, Sprague, Kissinger & McBurney (1940), and is used in therapy as its hydrochloride, Ambamide (formerly Marfanil). Its antibacterial properties were studied by Klartr (1941) who found it to be less active than sulphanilamide against streptococci, but more active against anaerobic bacteria (cf. Schoop & Stoltz, 1941 Hamre, Walker,...

The present paper augments information previously published on the first 25 patients with scrub typhus to receive chloromycetin (1) and reviews our experience in the use of this drug in the treatment of a total of 69 persons who contracted tsutsugamushi disease in the vicinity of Kuala Lumpur, Federation of Malaya. The results obtained in this group are compared with those observed in 19 patien...