We report the synthesis and characterization of high-molecular weight poly(l-glutamic acid) based brush polymers. Utilizing a combination of ring-opening metathesis polymerization of norbornene based monomers and ring-opening polymerization of γ-benzyl-l-glutamate N-carboxyanhydride, high-molecular weight γ-benzyl protected poly(l-glutamic acid) brush polymers are synthesized. Controlled and co...

The objective of the present work was to develop stomach specific delivery systems for am xicillin and metronidazole using chitosan and poly(acrylic acid) hydrogels. Chitosan and poly(acrylic acid) hydrogels were prepared with different composition of copolymers. The hydrogels were evaluated for swelling studies, mucoadhesive studies, in vitro drug release, scanning electron microscopic and FTI...

Drug-drug interactions (DDIs) are one of the commonest causes of medication error in developed countries, particularly in the elderly due to poly-therapy, with a prevalence of 20-40%. In particular, poly-therapy increases the complexity of therapeutic management and thereby the risk of clinically important DDIs, which can both induce the development of adverse drug reactions or reduce the clini...

The design and preparation of new polyester dendrimer, poly(ethylene oxide) hybrid systems for drug delivery and related therapeutic applications, are described. These systems consist of two covalently attached polyester dendrons, where one dendron provides multiple functional handles for the attachment of therapeutically active moieties, while the other is used for attachment of solubilizing p...

The treatment for many diseases can be improved by developing more efficient peptide delivery technologies, for example, biodegradable polymers. In this work, photocrosslinked poly(ester anhydride)s based on functionalized poly(ε-caprolactone) oligomers were investigated for their abilities to achieve controlled peptide delivery. The effect of oligomer hydrophobicity on erosion and peptide rele...

Biodegradable thermogelling copolymer hydrogels have great applicative potential in areas such as sustained drug release, gene delivery and tissue engineering. These injectable materials can be implanted in the human body with minimal surgical intervention. The thermosensitive copolymers have been incorporated with a variety of biocompatible and biodegradable components such as poly(D,L-lactic ...

Understanding the nanoscale structure of polymeric micelles is challenging: their relatively small size tests limits most experimental techniques, while great conformational flexibility individual polymer chains makes deriving insight from computer simulations difficult. Pluronics and Tetronics are amphiphilic block copolymers based on poly(ethylene oxide) poly(propylene blocks that self-assemb...