Abstract Nanoparticles (NP) comprised of poly(lactic-co-glycolic acid) (PLGA) and poly(lactic (PLA) have been shown to be effective delivery systems for peptide protein antigens (Ags) capable modulating Ag-specific T cell responses. Encapsulation surface conjugation are common Ag association methods using NPs. However, these associated with caveats such as imprecise loading, high burst release,...

Targeted cancer therapy allows the delivery of therapeutic agents to cancer cells without incurring undesirable side effects on the neighboring healthy tissues. Over the past decade, there has been an increasing interest in the development of advanced cancer therapeutics using targeted nanoparticles. Here we describe the preparation of drug-encapsulated nanoparticles formulated with biocompatib...

Nanoparticles made of poly(butyl cyanoacrylate) (PBCA) or poly(lactic-co-glycolic acid) (PLGA) coated with polysorbate 80 or poloxamer 188 enable the transport of cytostatics such as doxorubicin across the blood-brain barrier (BBB). Following intravenous injection to rats bearing intracranially the very aggressive glioblastoma 101/8 these particles loaded with doxorubicin significantly increase...