نتایج جستجو برای: polyamides
تعداد نتایج: 721 فیلتر نتایج به سال:
Designer molecules that can speci®cally target pre-determined DNA sequences provide a means to modulate endogenous gene function. Different classes of sequence-speci®c DNA-binding agents have been developed, including triplex-forming molecules, synthetic polyamides and designer zinc ®nger proteins. These different types of designer molecules with their different principles of engineered sequenc...
Gene amplification and/or overexpression of the transcription factor c-MYC, which binds to the E-box sequence (5'-CACGTG-3'), has been observed in many human tumors. In this study, we have designed 5 pyrrole-imidazole (PI) polyamides recognizing E-box, and found that, among them, Myc-6 significantly suppresses malignant phenotypes of human osteosarcoma MG63 cells both in vitro and in vivo. Intr...
Two advances in the synthesis of hairpin pyrrole-imidazole polyamides (PAs) are described. First, the application of a convergent synthetic strategy is shown, involving the Boc-based solid phase synthesis of a C-terminal fragment and the solution phase synthesis of the N-terminal fragment. Second a new hybrid resin is developed that allows for the preparation of hairpin PAs lacking a C-terminal...
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