Objectives: The purpose of this research work was to formulate and systemically evaluate in vitro performances polymeric microspheres nifedipine. Methods: Nifedipine containing two polymers, poloxamer 407 carbopol 934, were prepared by single emulsion cross-linking technique. Glutaraldehyde selected as the agent. A Box–Behnken design employed study effect independent variables, polymer concentr...

Floating microspheres have emerged as a potential candidate for gastroretentive drug delivery system. For developing a desired intragastric floatation system employing these microspheres, it is necessary to select an appropriate balance between buoyancy and drug releasing rate. These properties mainly depend on the polymers used in the formulation of the microspheres. Hence it is necessory to s...

A mathematical reaction-diffusion model is defined to describe the gradual decomposition of polymer microspheres composed of poly(D,L-lactic-co-glycolic acid) (PLGA) that are used for pharmaceutical drug delivery over extended periods of time. The partial differential equation (PDE) model treats simultaneous first-order generation due to chemical reaction and diffusion of reaction products in s...

The present study was carried out to formulate and evaluate sustained release floating microspheres of Carbamazepine using ethyl cellulose as the retardant material with high entrapment efficiency and extended release. A 2 factorial design was employed in formulating the GFDDS with Polymer-to-Drug ratio (X1), Acetone-toDichloromethane ratio (X2), and Stirring Speed (X3) as Independent Variables...

In the present study, Chitosan microspheres containing Trospium chloride were prepared by coacervation phase separation method and characterized by optical microscopy and scanning electron microscopy. The microspheres were analyzed for drug entrapment, bulk density, angle of repose, particle size and In-vitro release pattern. The effect of process variables on microsphere size was studied and b...

The aim of our studies was to formulate a system that delivers the required radiation dose to the tumor site and minimize the harm to other organs or tissues. The poly (lactic-co-glycolic acid, 75:25; 50:50) microspheric radiation delivery system was fabricated using double emulsion solvent evaporation technique for the encapsulation of technetium-99m(V)dimercaptosuccinic acid ((99m)Tc(V)DMSA)....

OBJECTIVES This study was designed to develop alginate-chitosan microspheres as drug carriers to reduce dose/dosing frequency in the management of tuberculosis (TB), which otherwise demands prolonged chemotherapy. METHODS Alginate-chitosan microspheres encapsulating three frontline anti-tuberculous drugs (ATDs), rifampicin, isoniazid and pyrazinamide, were formulated. A therapeutic dose and a...

The present study reports the potential application of star-shaped poly(?-caprolactones) with different number arms as new drug delivery matrix. Linear and PCL ibuprofen loaded microspheres were prepared using oil-in-water (o/w) solvent evaporation technique characterized FTIR, DSC, XRD SEM analysis. High yield, encapsulation efficiency loadings obtained for all microspheres. FTIR analysis reve...

In this study, a solvent evaporation technique was used to fabricate poly(3hydroxybutyrate-co-3-hydroxyvalerate) (PHBV, 8% PHV) microspheres as scaffold to guide liver cell growth. Human hepatoma cell lines, HepG2 and Hep3B, were cultured in vitro on both the microspheres and polymer films. SEM and optical microscope images showed that multilayer cells were formed among the microspheres to brid...

We investigated the effects of the rate of solvent removal by varying ambient pressure at a fixed temperature on the morphology, particle sizes, drug encapsulation efficiency and releases pattern of lidocaine loaded poly-L-lactatide (PLLA) and poly-D,L-lactatide (PDLLA) microspheres, prepared with O/W emulsion–solvent evaporation process. Prepared in the fast rate of solvent evaporation (FRSE) ...