Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases. It is characterized by uncontrolled cell proliferation and an absence of cell death that, except for hematological cancers, generates an abnormal cell mass or tumor. This primary tumor grows thanks to new vascularization and, in time, acquires metastatic potential and spreads to other body sites, which caus...

AIMS to design calcium and zinc-loaded bioactive and cytocompatible nanoparticles for the treatment of periodontal disease. METHODS PolymP-nActive nanoparticles were zinc or calcium loaded. Biomimetic calcium phosphate precipitation on polymeric particles was assessed after 7 days immersion in simulated body fluid, by scanning electron microscopy attached to an energy dispersive analysis syst...

We report a nanoimprint lithography method combined with photolithography on a bi-layer polymer setup to define nano-worms laterally in nano-gratings and produce uniform worm-shaped polymeric nanoparticles in aqueous solution by dissolving water soluble sacrificial layer poly(vinyl alcohol) (PVA). Process control of the thin residue layer, SU-8 curing using broadband UV source, and warm develop...

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Alternatively, star polymers (unimolecular, globular, polymer architectures) are an increasingly attractive class of organic nanoparticles for biomedical research purposes. [ 16–18 ] Although topographically similar to dendrimers (i.e., a high local density of polymeric arms, surface functionality, and interstitial regions), they lack the synthetic and structural limitations of dendrimers [ 19 ...

The process of opsonization is one of the most important biological barriers to controlled drug delivery. Injectable polymeric nanoparticle carriers have the ability to revolutionize disease treatment via spatially and temporally controlled drug delivery. However, opsonin proteins present in the blood serum quickly bind to conventional non-stealth nanoparticles, allowing macrophages of the mono...