The purpose of this study was to monitor the physicochemical properties atorvastatin calcium sesquihydrate (ATC) ground products during grinding and explore polymorphous formation caused by intermolecular interactions. Changes in properties, such as surface adsorbed channel water content ( AW ), lattice BW crystallinity XRD% apparent solubility Cs were evaluated via X-ray diffractometry, thermo...

A novel analytical method for the determination of pharmaceutical polymorphs was developed using terahertz spectroscopy. It was found out that each polymorph of a substance showed a specific terahertz absorption spectrum. In particular, analysis of the second derivative spectrum was enormously beneficial in the discrimination of closely related polymorphs that were difficult to discern by powde...

Scientific workflow systems provide languages for representing complex scientific processes as decompositions into lower level tasks, down to the level of atomic, executable units. To support data analysis activities, a wide variety of such languages represent data transformation and processing operations as task nodes within a workflow. Adding data type information to the task inputs and outpu...

Language-based security relies on the assumption that all potential attacks are bound by the rules of the language in question. When programs are compiled into a different language, this is true only if the translation process preserves observational equivalence. We investigate the problem of fully abstract compilation, i.e., compilation that both preserves and reflects observational equivalenc...

Nonself recognition in filamentous fungi is conferred by genetic differences at het (heterokaryon incompatibility) loci. When individuals that differ in het specificity undergo hyphal fusion, the heterokaryon undergoes a programmed cell death reaction or is highly unstable. In Neurospora crassa, three allelic specificities at the het-c locus are conferred by a highly polymorphic domain. This do...

Article history: Received on: 11/05/2016 Revised on: 30/06/2016 Accepted on: 16/08/2016 Available online: 29/10/2016 Mefenamic acid (MFA) and Nicotinamide (NIC) cocrystal formation in co-milling treatment was investigated by x-ray powder diffractometry (XRPD). Two polymorphic form of Mefenamic acid (MFA form I and MFA form II) were used to form a cocrystal with nicotinamide. Co-milling treatmen...

Atoms and de Bruijn indices are two well-known representation techniques for data structures that involve names and binders. However, using either technique, it is all too easy to make a programming error that causes one name to be used where another was intended. We propose an abstract interface to names and binders that rules out many of these errors. This interface is implemented as a librar...

Alteration in epidermal growth factor receptor (EGFR) expression is frequently associated with malignant transformation of epithelial tissues, including oral mucosa. This study examines the mutations in the coding region of the human EGFR gene in normal and malignant human oral keratinocytes. To examine the intragenic mutations in the human EGFR gene, a panel of normal and malignant human oral ...

Polymorphic gates are unconventional circuit components that are not supported by existing synthesis tools. This article presents new methods for synthesis of polymorphic circuits. Proposed methods, based on polymorphic binary decision diagrams and polymorphic multiplexing, extend the ordinary circuit representations with the aim of including polymorphic gates. In order to reduce the number of ...

Exceptions are an indispensable part of modern programming languages. They are, however, handled poorly, especially by higherorder languages such as Standard ML and Haskell: in both languages a well-typed program can unexpectedly fail due to an uncaught exception. In this paper, we propose a technique for type-safe exception handling. Our approach relies on representing exceptions as sums and a...