Picornaviruses are inactivated by a family of hydrophobic drugs that bind at an internal site in the viral capsid and inhibit viral uncoating. A basis for the capsid stabilization previously unrecognized is revealed by molecular dynamics simulations of the antiviral drug WIN52084s bound to a hydrophobic pocket of solvated human rhinovirus 14. Isothermal compressibilities of the complex and huma...

Compressibility of a soil mass is its susceptibility to decrease in volume under pressure and is indicated by soil characteristics like coefficient of compressibility, compression index and coefficient of consolidation. However, the determination of soil compressibility characteristics in the labs is a cumbersome and time consuming process, especially in the case of fine grained soils. In the p...

We performed a systematic evaluation of ‘visually lossless’ (VL) threshold selection for H.264/AVC (Advanced Video Coding) compressed natural videos spanning a wide range of content and motion. A psychovisual study was conducted using a two alternative forced choice task design, where by a series of reference vs. compressed video pairs were displayed to the subjects, where bit rates were varied...

We present a new computational approach to quantify the area per lipid and the area compressibility modulus of biological membranes. Our method relies on the analysis of the membrane fluctuations using our recently introduced coupled undulatory (CU) mode [Tarazona et al., J. Chem. Phys. 139, 094902 (2013)], which provides excellent estimates of the bending modulus of model membranes. Unlike the...

the dried fruit of terminalia chebula is widely used for its laxative properties. the objective of the present study was to examine the flowability and compressibility of terminalia chebula fruit powder, subsequently developing its tablet formulations by utilizing wet granulation and direct compression technology. initial studies on flowability and compressibility revealed that the fruit powder...

Objective(s):The aim of this study was to improve flowability and compressibility characteristics of starch to use as a suitable excipient in direct compression tabletting. Quasi-emulsion solvent diffusion was used as a crystal modification method. Materials and Methods: Corn starch was dissolved in hydrochloric acid at 80˚C and then ethanol as a non-solvent was added with lowering temperature ...

Aqueous solutions of mono, di, and triprotic acids were prepared with different molar percentages (say 10%, 20% and 30%). ammonium dihydrogen phosphate is gradually introduced in the aqueous solutions at different concentrations varied from 0.1M to 0.6M at 303K. Densities, viscosities, and velocity of sound of aqueous solutions are measured and they are used to evaluate the other parameters lik...

The effect of carbon dioxide (CO2) sorption on the lower critical solution temperatures of deuterated polybutadiene/polyisoprene blends was determined with in situ small-angle neutron scattering. CO2 was a poor solvent for both polymers and exhibited very weak selectivity between the blend components. The sorption of modest concentrations of CO2, at pressures up to 160 bar, induced phase segreg...

Abstract—In this paper, analysis of an infinite beam resting on multilayer tensionless extensible geosynthetic reinforced granular fill-poor soil system overlying soft soil strata under moving load with constant velocity is presented. The beam is subjected to a concentrated load moving with constant velocity. The upper reinforced granular bed is modeled by a rough membrane embedded in Pasternak...

Magma chamber volume is critical for volcano hazards assessment and forecasting. Standard geodetic methods constrain change, not the total volume. Here, we show that deformation response of magma to trapdoor faulting events at Sierra Negra volcano, Galapagos, depends on product absolute compressibility. Bubble-free provides lower limit compressibility, thus an upper bound 13.6–20.6 km3, dependi...