Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that by timely reperfusion is needed to reduce infarct size and improve the prognosis of patients with acute myocardial infarction. The conditioning phenomena provide such cardioprotection, insofar as brief episodes o...

Perioperative myocardial ischemia and infarction are not only major sources of morbidity and mortality in patients undergoing surgery but also important causes of prolonged hospital stay and resource utilization. Ischemic and pharmacological preconditioning and postconditioning have been known for more than two decades to provide protection against myocardial ischemia and reperfusion and limit ...

Intracranial aneurysms and their treatment is one of the leading problems of neurosurgery that create high mortality and morbidity. The technique of safe clipping is as generally used depends on the temporary occlusion of the cerebral vasculature during surgery. However, there is no exact data about temporary clipping or timing of this procedure. Preconditioning by exposure to sublethal hypoxic...

Following classical fear conditioning, Ss were trained to jump a hurdle to escape the fear-eliciting stimuli. 2 groups were conditioned in the start box of the hurdle apparatus (Same CB) and 2 in a separate, but similar, conditioning box (Diff CB). Under each condition, 1 group had hurdle training after a 3-min., and the other, after a 24-hr., postconditioning delay. For the 2 Diff CB groups, h...

OBJECTIVE To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs. METHODS Wistar rats (n=24) divided into 3 groups: GA (I/R) n=8, GB (R-Po) n=8, CG (control) n=8, underwent ischemia for 30 minutes artery occlusion abdominal aorta, followed by reperfusion for 60 minutes. Resected lungs and performed histological analysis and classification of morphological...

Joseph T. McCabe1, Michael W. Bentley2 and Joseph C. O’Sullivan2 1Department of Anatomy, Physiology & Genetics, and The Center for Neuroscience & Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 2U.S. Army Graduate School of Anesthesia Nursing, Graduate School, AMEDD Center and School, Academy of Health Sciences, Fort Sam Houston, San Antonio, Texa...

Erythropoietin (EPO) is an important regulator of the production red blood cells, and cloning of the gene led to the development of recombinant human EPO preparation, rhEPO. EPO caught the public eye when some leading athletes started to take it to increase the oxygen-carrying capacity of the blood and, thereby, to achieve enhanced athletic performance. Thus, they were conveniently able to achi...