Intraocular lenses (IOLs) are implanted during cataract surgery. For optimum results, stable positioning of the IOL in capsular bag is important. Wound-healing events following surgery lead to modification and secondary visual loss due posterior capsule opacification. At present, it unclear how these biological can affect stability within bag. In present study, a human vitro graded culture mode...

Aberrant proliferation and migration of residual lens epithelial cells (LECs) is the main cause posterior capsule opacification (PCO) after cataract surgery. The purpose this study was to confirm protective effects Astragaloside IV (AST) in transforming growth factor beta (TGF-β)-induced LECs. Human LECs, SRA01/04, were used study. MTT assay EdU perform cell viability proliferation, respectivel...

Introduction Cataract surgery is the most frequently performed surgical procedure in UK and posterior capsule opacification (PCO) common complication post-surgery. Nd:YAG capsulotomy standard of care for treating PCO, although it bears a cost also associated with complications. The objective this research was to estimate costs from budget holders perspective PCO related, post-cataract resource ...

PURPOSE We investigated the effect of epidermal growth factor receptor (EGFR) siRNA on human lens epithelium (HLE) cells and the development of posterior capsular opacity (PCO). METHODS We designed EGFR siRNA and used it to knockdown the expression of EGFR in HLE cells. Cell proliferation was examined by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), cell growth curve ass...

BACKGROUND This paper presents and tests a comprehensive computerised system of analysis of digital images of posterior capsule opacification (PCO). It updates and expands significantly on a previous presentation to include facilities for selecting user defined central areas and for registering and subsequent merging of images for artefact removal. Also, the program is compiled and thus elimina...

purpose: to compare the visual outcomes and complications of lensectomy and posterior chamber intraocular lens (pciol) implantation with or without posterior capsulotomy and anterior vitrectomy in pediatric cataracts. methods: seventeen eyes of 12 children aged 10 to 15 years with congenital or developmental cataract were randomly divided into two groups. lensectomy and pciol implantation was p...

AIM To determine the visual benefit of cataract extraction in patients with retinitis pigmentosa and to identify risk factors for poor outcome. METHODS A retrospective analysis was undertaken of a continuous series of 142 eyes of 89 patients with retinitis pigmentosa undergoing cataract surgery between 1985 and 1997. RESULTS Mean age at surgery was 47.5 years (range 24-81 years). In 100 eye...

AIM To evaluate the image quality produced by polypseudophakia used for strongly hypermetropic and nanophthalmic eyes. METHODS Primary aberration theory and ray tracing analysis were used to calculate the optimum lens shapes and power distribution between the two intraocular lenses for two example eyes: one a strongly hypermetropic eye, the other a nanophthalmic eye. Spherical aberration and ...