INTRODUCTION Post-operative agitation (PA) is a common problem (20-70%) in children anaesthetised with sevoflur-ane. Clonidine is widely used off-label in children for several indications, including PA, but the current level of evidence is limited. Our aim is to investigate the impact of prophylactic intravenous (IV) clonidine administered at the end of surgery on the incidence and degree of PA...

BACKGROUND Agitation in Alzheimer's disease (AD) is common and associated with poor patient life-quality and carer distress. The best evidence-based pharmacological treatments are antipsychotics which have limited benefits with increased morbidity and mortality. There are no memantine trials in clinically significant agitation but post-hoc analyses in other populations found reduced agitation. ...

OBJECTIVE A prospective, double-blind, randomized controlled trial to compare the effect of preoperative midazolam or ketamine on the incidence of emergence agitation (EA) following sevoflurane anaesthesia in children. METHODS Paediatric patients (2-6 years old) undergoing ophthalmic surgery were allocated to receive premedication with either 0.1 mg/kg midazolam or 1 mg/kg ketamine. Incidence...

The first patient described by Alzheimer in 1907 had both progressive cognitive deterioration and prominent comorbid signs and symptoms of psychosis and agitation (Alzheimer, 1907, 1987). In this editorial, we use “psychosis” to denote delusions and hallucinations and “agitation” to denote irritability, aggression, pressured motor activity, and active resistance to necessary care. Although adva...

Background: The intranasal route is a reliable way to administer preanaesthetics and sedatives children. aim of present study was compare the anxiolytic sedative effects dexemedetomidine midazolam as premedication in children with congenital heart disease undergoing cardiac surgery.. Patients Methods: Fifty chidrens 2-12 years age group either sex surgery were randomly allocated into two groups...

Delirium is a syndrome consisting of cloudiness of consciousness,attention deficit,and cognitive impairment,with quick onset,but varring paths in its progression .delirium is more common after major surgeries in the elderly and hospitalized patients,resuting in high morbidity and mortality rates.the incidence rate that has been reported  in previous studies varies from 1-3% in cataract surgery ...

Agitation and aggression are some of the most frequent and disruptive neuropsychiatric symptoms in patients with dementia. Approximately 45% to 80% of patients with dementia will exhibit agitation and aggression, depending on the clinical setting and dementia stage.1 Agitation and aggression have a major negative impact on disease burden, with higher incidence of functional decline and loss of ...