A simple and efficient TEMPO-mediated system for aerobic oxidative synthesis of 2-aryl benzoxazoles from readily available primary benzylic hetero amines is presented in one pot. The reaction proceeds through the ring-opening followed by condensation with benzylamines. These metal-free, straightforward reactions worked well a wide range substrates, yielding moderate to good yields under mild co...

A convenient synthetic method for the synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetra substituted imidazole derivatives, has been developed via one-pot condensation reaction in solvent-free condition when aldehyde, ammonium acetate/amine, and 1,2-diketone are reacted using 0.8 mol% of NP-LaMnO3 at 80 °C under solvent free conditions. Catalyst could be recovered and reused in five reaction c...

For the first time lactic acid was applied as an efficient and green catalyst for the one-pot three-component synthesis of amidoalkyl naphthols via the condensation between arylaldehydes, 2-naphthol and amides or urea under thermal solvent-free conditions in good to excellent yields. We have demonestrated a mild and efficient eco-friendly tandem synthesis of amidoalkyl naphthols using lactic ac...

Sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) as a new nanoporous acid catalyst was used in the one-pot synthesis of polyhydroquinolines derivatives via the Hantzsch four component condensation reaction of aldehydes, b-ketoesters, dimedone and ammonium acetate under solvent free conditions with short reaction time in excellent yields. SBA-P...

An improved and greener protocol for the synthesis of benzimidazole derivatives, starting from o-phenylenediamine, with different aldehydes is reported. Double-condensation products were selectively obtained when Er(OTf)3 was used as the catalyst in the presence of electron-rich aldehydes. Conversely, the formation of mono-condensation products was the preferred path in absence of this catalyst...

A facile and efficient protocol for the synthesis of 1,8-dioxo-octahydroxanthenes has been developed by one-pot Knoevenagel condensation, Michael addition and cyclodehydration reaction of dimedone (active methylene carbonyl compound) with aromatic aldehydes in the presence of Iron (III) sulfate hydrate as a solid acidic catalyst under solvent-free conditions. Various aromatic aldehydes were uti...

Selectfluor [1-(chloro methyl) -4-flouro -1,4-di azonia bicyclo[2,2,2] octane bis (tetraflouro-borate)] catalyzed the preparation of quinoxaline and 2,3-dihydo pyrazine derivatives through one -pot condensation of 1,2-di amines with 1,2-di carbonyls in solvent and under solvent- free conditions. This catalyst is commercially available, inexpensive, reusable, stable to air and moisture, and rela...

an efficient, mild and environmentally friendly method was reported for the synthesis of an efficient, mild and environmentally friendly method was reported for the synthesis of pyranopyroles from aryl aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate in the presence of catalytic amounts of methyl imidazolium hydrogen sulfate ([hmim][hso4]) as an efficient catalyst. these synth...

One pot synthesis of terpyrromethanes (3a) and [di(1H-pyrrol-2-yl)methyl]heteroarenes (3b-m) has been delineated by Amberlyst 15 catalyzed condensation of pyrrole and heterocyclic aldehydes (2), not reported earlier. The compounds 3a and 3b have been formylated to 5-[di(5-formyl-1H-pyrrol-2-yl)methyl]-1H-pyrrole-2-carbaldehyde (4a) and 5[(5-formyl-1H-pyrrol-2-yl)(3-pyridinyl)methyl]-1H-pyrrole-...

Copper(II)/polyimide-linked covalent organic frameworks under solvent-free and microwave-assisted conditions have been used in an efficient one-pot protocol for the preparation of 2,4,5-trisubstituted imidazoles via benzil, aromatic aldehydes ammonium acetate. By applying microwave irradiation, three-component condensation provides safe operations, low pollution, quick access to products, easy ...