Parkinson’s disease (PD) is a progressive neurodegenerative that characterized by the loss of dopamine. Since dopamine has trouble entering blood–brain barrier, utilization dendrimers and other nanomaterials considered for conjugating neurotransmitter PD drugs. Dendrimers are three-dimensional, hyper-branched structures categorized into several generations. Alpha-synuclein (ASN) protein involve...

Fibromyalgia is characterized by the amplification of central nervous system pain with concomitant fatigue, sleep, mood disorders, depression, and anxiety. It needs extensive pharmacological therapy. In present study, Swiss mice were treated reserpine (0.25 mg/kg, s.c.) over three consecutive days, in order to reproduce pathogenic process fibromyalgia. On day 4, administrations Tx3-3 toxin prod...