Human papilloma virus (HPV)-16 and -18 are responsible for approximately 70% of invasive cervical cancers worldwide. Other oncogenic HPV types account for almost all the remainder. Importantly, HPV-45 and -31 account for approximately 10%. HPV-18 and -45, along with HPV-16, are found in over 90% of endocervical adenocarcinomas. HPV-45 is the third most frequent HPV type in cervical carcinoma an...

Prediction of the clinical outcome of nonadvanced, early dysplastic lesions is one of the unresolved problems of cervical cancer screening programs. We examined the influence of human papillomavirus (HPV) L1 capsid protein detection in a randomized, prospective study of 187 high-risk HPV+ early dysplastic lesions during 36 to 46 months. The difference in the clinical outcome of the HPV L1- case...

The main etiological factor of precancerous lesion and invasive cervical cancer are oncogenic human papillomaviruses types (HPVs). The objective of this study was to establish the distribution of the most common HPVs in different cervical lesions and cancer prior to the implementation of organized population-based cervical screening and HPV vaccination in Croatia. In this study, 4,432 cervical ...

Abstract Objective To assess the prevalence and distribution of HPV genotypes among Chinese Han women, to explore risk high-grade cervical lesions associated with individual hr-HPV genotypes. Methods Genotyping histopathology data from Multi-Center Screening Trial (CHIMUST) its pilot screening trial, 6 regions across mainland China, were re-analyzed. The physician- self-collected samples 10,867...

Sanner, K. 2013. Significance of Human Papillomavirus (HPV) Analysis for the Detection of Precancerous Cervical Lesions: Impact of Self Sampling. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 877. 63 pp. Uppsala. ISBN 978-91-554-8621-1. Cervical cancer is the second most common cancer, with about 500 000 new cases per year ...

OBJECTIVE We attempted to reveal the changes of the human telomerase reverse transcriptase (hTERT) alternative splicing pattern in gastric carcinogenesis. METHODS Three alternative splicing sites (alpha, beta, gamma) were selected and designed PCR primer. The expression of 8 hTERT alternative splicing variants (ASVs) in normal gastric mucosa, precancerous lesions and gastric cancer were detec...

this study has been designed to compare visual inspection of cervix with acetic acid (via test) with cytology as an accepted method for screening of cervical carcinoma and its precursors. 1200 eligible women were examined by both pap-smear and via tests in imam khomeini hospital, a referral general hospital in tehran, iran. those who had abnormal results in one or both of the screening tests (n...

the previous studies reported some information about prevalence release of high-risk hpv types in hsil or cervical cancer globally and in iran, however, this information is not enough for final judgment about vaccination against hpv or any screening program. the aim of the present study was to assess the hpv type distribution in hsil and icc specimens of women attending shahid beheshti universi...

Abstract Modern therapeutic strategies for precancerous cervical intraepithelial neoplasia (CIN) focus on immune-modulatory and cancer vaccination. The local immune status in CIN could influence HPV infection persistence, progression carcinogenesis. We analysed the role of FOXP3+ regulatory T lymphocytes, CD4+ CD8+ lymphocytes I, II III patients with without infection. Sixty-two were enrolled s...

With the introduction of cervical screening programs, the incidence and mortality of cervical cancer has been drastically reduced. Techniques such as the traditional Papanicolaou test and the newer liquid-based cytology allow for the early detection of cervical abnormalities prior to the development of invasive cervical cancer. As oncogenic human papillomavirus (HPV) infection is necessary for ...